Zelkovamycins B–E, cyclic octapeptides containing rare amino acid residues from an endophytic Kitasatospora sp

Xiaomeng Hao, Jiaqing Yu, Yujia Wang, Jack A. Connolly, Yufeng Liu, Yuqin Zhang, Liyan Yu, Shan Cen, Rebecca J. M. Goss, Maoluo Gan

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Four unusual cyclopeptides, zelkovamycins B–E (1–4), were isolated from an endophytic Kitasatospora sp. Zelkovamycin B was featured by an unprecedented 3-methyl-5-hydroxypyrrolidine-2,4-dione ring system linked to the cyclopeptide skeleton. Their structures and full configurations were established by spectroscopic analysis, Marfey’s method, and NMR calculations. A plausible biosynthetic pathway for zelkovamycins was proposed based on gene cluster analysis. Zelkovamycin E displayed potent inhibitory activity against H1N1 influenza A virus.
Original languageEnglish
JournalOrganic Letters
VolumeArticles ASAP
Early online date20 Nov 2020
DOIs
Publication statusE-pub ahead of print - 20 Nov 2020

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