Wrapped in the Strong Arms of the Union: Shakespeare and King James

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34 Citations (Scopus)

Abstract

Background. Acute phase protein production is a hallmark of severe burns. We wondered whether anabolic treatment with oxandrolone would affect these proteins.

Methods. Thirty-five children with greater than or equal to40% total body surface area burns were randomized to receive either placebo or oxandrolone (0.1 mg/kg by mouth twice daily) from postoperative day 5 to 1 year postburn. Levels of constitutive proteins and acute phase proteins were measured at admission, at discharge; and at 6, 9, and 12 months after burn. Total albumin supplementation and hepatic transaminases were also assessed.

Results. Constitutive proteins such as albumin, prealbumin, and retinol-binding protein levels increased (p < 0.05), and acute phase proteins such as alpha(1)-acid glycoprotein, C3 complement, alpha(2)-macroglobulin, and fibrinogen levels significantly decreased in the oxandrolone group compared with placebo (p < 0.05). Albumin supplementation during the acute hospitalization was reduced in the oxandrolone group. Hepatic transaminases remained within normal levels.

Conclusion:. Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels.

Original languageEnglish
Title of host publicationShakespeare and Scotland
EditorsW Maley, A Murphy
PublisherManchester University Press
Pages37-52
ISBN (Print)0719066360, 0719066379
DOIs
Publication statusPublished - Jan 2004

Keywords

  • oxandrolone
  • constitutive proteins
  • acute phase proteins
  • severe burns
  • albumin
  • prealbumin
  • retinol-binding protein
  • transferrin
  • alpha(1)-acid glycoprotein
  • alpha(2)-macroglobulin
  • haptoglobin
  • C-reactive protein
  • C3 complement
  • hypermetabolism
  • HUMAN GROWTH-HORMONE
  • NUTRITIONAL SUPPORT
  • SURVIVAL
  • THERAPY
  • INJURY
  • MASS
  • GAIN

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