Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer’s disease

Doris Chen; Wanjia Yu; Laura Aitken; Frank J Gunn-Moore

doi:10.3390/cells10113024

Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer’s disease

Doris Chen, Wanjia Yu, Laura Aitken, Frank J Gunn-Moore^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Physiological functions of Willin/FRMD6 in the nervous system include neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. The newly established neuronal role of Willin/FRMD6 is of particular interest given the mounting evidence suggesting a role for Willin/FRMD6 in Alzheimer’s disease (AD), including a series of genome wide association studies that position Willin/FRMD6 as a novel AD risk gene. Here we describe recent findings regarding the role of Willin/FRMD6 in the nervous system and its actions in cellular perturbations related to the pathogenesis of AD.

Original language	English
Article number	3024
Number of pages	27
Journal	Cells
Volume	10
Issue number	11
DOIs	https://doi.org/10.3390/cells10113024
Publication status	Published - 4 Nov 2021

Keywords

Oxidative stress
Willin/FRMD6
Hippo signaling
Alzheimer’s disease
Neurodegeneration
Mecha-17 notransduction

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10.3390/cells10113024Licence: CC BY

Chen-2021-Willin-FRMD6-a-multifunctional-Cells-10-03024-CCBY
Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Final published version, 1.39 MBLicence: CC BY

Resonant and shaped photonics for under: Resonant and shaped photonics for understanding the physical and biomedical world
Gunn-Moore, F. J. (PI)
EPSRC
1/08/17 → 31/07/22
Project: Standard

Cite this

@article{98cb254a7c254b909d21f02535098951,

title = "Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer{\textquoteright}s disease",

abstract = "The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Physiological functions of Willin/FRMD6 in the nervous system include neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. The newly established neuronal role of Willin/FRMD6 is of particular interest given the mounting evidence suggesting a role for Willin/FRMD6 in Alzheimer{\textquoteright}s disease (AD), including a series of genome wide association studies that position Willin/FRMD6 as a novel AD risk gene. Here we describe recent findings regarding the role of Willin/FRMD6 in the nervous system and its actions in cellular perturbations related to the pathogenesis of AD.",

keywords = "Oxidative stress, Willin/FRMD6, Hippo signaling, Alzheimer{\textquoteright}s disease, Neurodegeneration, Mecha-17 notransduction",

author = "Doris Chen and Wanjia Yu and Laura Aitken and Gunn-Moore, {Frank J}",

note = "This research was funded by the EPSRC, grant number EP/P030017 (D.C. and F.G-M), the China Scholarship Council (W.Y.), the Rosetrees Trust and the RS MacDonald Charitable Trust (L.A.).",

year = "2021",

month = nov,

day = "4",

doi = "10.3390/cells10113024",

language = "English",

volume = "10",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

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TY - JOUR

T1 - Willin/FRMD6

T2 - a multi-functional neuronal protein associated with Alzheimer’s disease

AU - Chen, Doris

AU - Yu, Wanjia

AU - Aitken, Laura

AU - Gunn-Moore, Frank J

N1 - This research was funded by the EPSRC, grant number EP/P030017 (D.C. and F.G-M), the China Scholarship Council (W.Y.), the Rosetrees Trust and the RS MacDonald Charitable Trust (L.A.).

PY - 2021/11/4

Y1 - 2021/11/4

N2 - The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Physiological functions of Willin/FRMD6 in the nervous system include neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. The newly established neuronal role of Willin/FRMD6 is of particular interest given the mounting evidence suggesting a role for Willin/FRMD6 in Alzheimer’s disease (AD), including a series of genome wide association studies that position Willin/FRMD6 as a novel AD risk gene. Here we describe recent findings regarding the role of Willin/FRMD6 in the nervous system and its actions in cellular perturbations related to the pathogenesis of AD.

AB - The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Physiological functions of Willin/FRMD6 in the nervous system include neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. The newly established neuronal role of Willin/FRMD6 is of particular interest given the mounting evidence suggesting a role for Willin/FRMD6 in Alzheimer’s disease (AD), including a series of genome wide association studies that position Willin/FRMD6 as a novel AD risk gene. Here we describe recent findings regarding the role of Willin/FRMD6 in the nervous system and its actions in cellular perturbations related to the pathogenesis of AD.

KW - Oxidative stress

KW - Willin/FRMD6

KW - Hippo signaling

KW - Alzheimer’s disease

KW - Neurodegeneration

KW - Mecha-17 notransduction

U2 - 10.3390/cells10113024

DO - 10.3390/cells10113024

M3 - Review article

SN - 2073-4409

VL - 10

JO - Cells

JF - Cells

IS - 11

M1 - 3024

ER -

Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer’s disease

Abstract

Keywords

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Resonant and shaped photonics for under: Resonant and shaped photonics for understanding the physical and biomedical world

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