Wide-field optical coherence microelastography for intraoperative assessment of human breast cancer margins

Wes M. Allen*, Lixin Chin, Philip Wijesinghe, Rodney W. Kirk, Bruce Latham, David D. Sampson, Christobel M. Saunders, Brendan F. Kennedy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.

Original languageEnglish
Article number268575
Pages (from-to)4139-4153
Number of pages15
JournalBiomedical Optics Express
Volume7
Issue number10
Early online date19 Sept 2016
DOIs
Publication statusPublished - 1 Oct 2016

Keywords

  • Medical optics and biotechnology
  • Optical coherence tomography

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