Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis

Xinyue Wang; William J. Jowsey; Chen-Yi Cheung; Caitlan J. Smart; Hannah R. Klaus; Noon E. J. Seeto; Natalie J. E. Waller; Michael T. Chrisp; Amanda L. Peterson; Boatema Ofori-Anyinam; Emily Strong; Brunda Nijagal; Nicholas P. West; Jason H. Yang; Peter C. Fineran; Gregory M. Cook; Simon A. Jackson; Matthew B. McNeil

doi:10.1038/s41467-024-54072-w

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis

Xinyue Wang, William J. Jowsey, Chen-Yi Cheung, Caitlan J. Smart, Hannah R. Klaus, Noon E. J. Seeto, Natalie J. E. Waller, Michael T. Chrisp, Amanda L. Peterson, Boatema Ofori-Anyinam, Emily Strong, Brunda Nijagal, Nicholas P. West, Jason H. Yang, Peter C. Fineran, Gregory M. Cook, Simon A. Jackson, Matthew B. McNeil

School of Medicine

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	9791
Number of pages	18
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-54072-w
Publication status	Published - 13 Nov 2024

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Wang, X., Jowsey, W. J., Cheung, C.-Y., Smart, C. J., Klaus, H. R., Seeto, N. E. J., Waller, N. J. E., Chrisp, M. T., Peterson, A. L., Ofori-Anyinam, B., Strong, E., Nijagal, B., West, N. P., Yang, J. H., Fineran, P. C., Cook, G. M., Jackson, S. A., & McNeil, M. B. (2024). Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis Nature Communications, 15(1), Article 9791. https://doi.org/10.1038/s41467-024-54072-w

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author = "Xinyue Wang and Jowsey, \{William J.\} and Chen-Yi Cheung and Smart, \{Caitlan J.\} and Klaus, \{Hannah R.\} and Seeto, \{Noon E. J.\} and Waller, \{Natalie J. E.\} and Chrisp, \{Michael T.\} and Peterson, \{Amanda L.\} and Boatema Ofori-Anyinam and Emily Strong and Brunda Nijagal and West, \{Nicholas P.\} and Yang, \{Jason H.\} and Fineran, \{Peter C.\} and Cook, \{Gregory M.\} and Jackson, \{Simon A.\} and McNeil, \{Matthew B.\}",

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doi = "10.1038/s41467-024-54072-w",

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Wang, X, Jowsey, WJ, Cheung, C-Y, Smart, CJ, Klaus, HR, Seeto, NEJ, Waller, NJE, Chrisp, MT, Peterson, AL, Ofori-Anyinam, B, Strong, E, Nijagal, B, West, NP, Yang, JH, Fineran, PC, Cook, GM, Jackson, SA & McNeil, MB 2024, 'Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis', Nature Communications, vol. 15, no. 1, 9791. https://doi.org/10.1038/s41467-024-54072-w

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AU - Klaus, Hannah R.

AU - Seeto, Noon E. J.

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AU - Ofori-Anyinam, Boatema

AU - Strong, Emily

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AU - West, Nicholas P.

AU - Yang, Jason H.

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AU - McNeil, Matthew B.

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Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of <i>Mycobacterium tuberculosis</i>

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