Whitehead et al. Respond.

Ross Whitehead, Gozde Ozakinci, Ian David Stephen, David Ian Perrett

Research output: Contribution to journalArticle

2 Citations (Scopus)


We agree that fruit and vegetable consumption is likely to confer health benefits by substituting refined carbohydrates, saturated fats, and other foodstuffs that are unambiguously deleterious to health. We argue, though, that fruit and vegetables convey additional active benefits to human health. While it is true that trials have consistently indicated that the impact of antioxidant supplement intake is null or negative, these studies highlight an overly reductionist approach. There exist important synergistic relationships between antioxidants(1); therefore, high-dose supplementation of a circumscribed subset of phytochemicals is unlikely to be beneficial. Breakdown products of some antioxidants are themselves toxic,(2) and because these antioxidants are readily expended by oxidizing agents when reserves of alternate endogenous antioxidants are low, administering high doses of single antioxidants could inadvertently precipitate oxidative tissue damage. As an example of the synergic relationships that exist, α-tocopherol oxidation toxicity is mitigated by carotenoids.(3)
Original languageEnglish
JournalAmerican Journal of Public Health
Publication statusPublished - 16 Aug 2012


Dive into the research topics of 'Whitehead et al. Respond.'. Together they form a unique fingerprint.

Cite this