Wheat germ agglutinin-modified trifunctional nanospheres fo cell recognition

H. Xie; M. Xie; Z. Zhang; Y. Long; X. Liu; M. Tang; D. Pang; Z. Tan; Calum Dickinson; Wuzong Zhou

doi:10.1021/bc060387g

Wheat germ agglutinin-modified trifunctional nanospheres fo cell recognition

H. Xie, M. Xie, Z. Zhang, Y. Long, X. Liu, M. Tang, D. Pang, Z. Tan, Calum Dickinson, Wuzong Zhou

Research output: Contribution to journal › Article › peer-review

Abstract

A simple and convenient strategy has been Put forward to fabricate smart fluorescent magnetic wheat germ agglutinin-modified trifunctional nanospheres (WGA-TFNS) for recognition of human prostate carcinoma DU-145 cells which are surface-expressed with sialic acid and N-acetylglucosamine. These TFNS can be easily manipulated, tracked, and conveniently used to capture and separate target cells. The presence of wheat germ agglutinin on the surface of WGA-TFNS was confirmed by FTIR, biorecognition of carboxymethyl chitin-modified quantum dots (CM-CT-QDs), and bacterium Staphylococcus aureus. The success in recognizing DU-145 cells by the WGA-TFNS indicates that WGA-TFNS could be applicable.

Original language	English
Pages (from-to)	1749-1755
Number of pages	7
Journal	Bioconjugate Chemistry
Volume	18
DOIs	https://doi.org/10.1021/bc060387g
Publication status	Published - Nov 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

QUANTUM DOTS
CANCER-CELLS
SEMICONDUCTOR NANOCRYSTALS
PLGA NANOPARTICLES
GENOMIC DNA
MAGNETITE
LECTIN
NANOCOMPOSITES
TECHNOLOGY
PARTICLES

Access to Document

10.1021/bc060387g

Cite this

@article{0738ccf4d25d42ac80225ec7f171e8e5,

title = "Wheat germ agglutinin-modified trifunctional nanospheres fo cell recognition",

abstract = "A simple and convenient strategy has been Put forward to fabricate smart fluorescent magnetic wheat germ agglutinin-modified trifunctional nanospheres (WGA-TFNS) for recognition of human prostate carcinoma DU-145 cells which are surface-expressed with sialic acid and N-acetylglucosamine. These TFNS can be easily manipulated, tracked, and conveniently used to capture and separate target cells. The presence of wheat germ agglutinin on the surface of WGA-TFNS was confirmed by FTIR, biorecognition of carboxymethyl chitin-modified quantum dots (CM-CT-QDs), and bacterium Staphylococcus aureus. The success in recognizing DU-145 cells by the WGA-TFNS indicates that WGA-TFNS could be applicable.",

keywords = "QUANTUM DOTS, CANCER-CELLS, SEMICONDUCTOR NANOCRYSTALS, PLGA NANOPARTICLES, GENOMIC DNA, MAGNETITE, LECTIN, NANOCOMPOSITES, TECHNOLOGY, PARTICLES",

author = "H. Xie and M. Xie and Z. Zhang and Y. Long and X. Liu and M. Tang and D. Pang and Z. Tan and Calum Dickinson and Wuzong Zhou",

year = "2007",

month = nov,

doi = "10.1021/bc060387g",

language = "English",

volume = "18",

pages = "1749--1755",

journal = "Bioconjugate Chemistry",

issn = "1520-4812",

publisher = "American Chemical Society (ACS)",

}

TY - JOUR

T1 - Wheat germ agglutinin-modified trifunctional nanospheres fo cell recognition

AU - Xie, H.

AU - Xie, M.

AU - Zhang, Z.

AU - Long, Y.

AU - Liu, X.

AU - Tang, M.

AU - Pang, D.

AU - Tan, Z.

AU - Dickinson, Calum

AU - Zhou, Wuzong

PY - 2007/11

Y1 - 2007/11

N2 - A simple and convenient strategy has been Put forward to fabricate smart fluorescent magnetic wheat germ agglutinin-modified trifunctional nanospheres (WGA-TFNS) for recognition of human prostate carcinoma DU-145 cells which are surface-expressed with sialic acid and N-acetylglucosamine. These TFNS can be easily manipulated, tracked, and conveniently used to capture and separate target cells. The presence of wheat germ agglutinin on the surface of WGA-TFNS was confirmed by FTIR, biorecognition of carboxymethyl chitin-modified quantum dots (CM-CT-QDs), and bacterium Staphylococcus aureus. The success in recognizing DU-145 cells by the WGA-TFNS indicates that WGA-TFNS could be applicable.

AB - A simple and convenient strategy has been Put forward to fabricate smart fluorescent magnetic wheat germ agglutinin-modified trifunctional nanospheres (WGA-TFNS) for recognition of human prostate carcinoma DU-145 cells which are surface-expressed with sialic acid and N-acetylglucosamine. These TFNS can be easily manipulated, tracked, and conveniently used to capture and separate target cells. The presence of wheat germ agglutinin on the surface of WGA-TFNS was confirmed by FTIR, biorecognition of carboxymethyl chitin-modified quantum dots (CM-CT-QDs), and bacterium Staphylococcus aureus. The success in recognizing DU-145 cells by the WGA-TFNS indicates that WGA-TFNS could be applicable.

KW - QUANTUM DOTS

KW - CANCER-CELLS

KW - SEMICONDUCTOR NANOCRYSTALS

KW - PLGA NANOPARTICLES

KW - GENOMIC DNA

KW - MAGNETITE

KW - LECTIN

KW - NANOCOMPOSITES

KW - TECHNOLOGY

KW - PARTICLES

UR - https://www.scopus.com/pages/publications/36849070422

U2 - 10.1021/bc060387g

DO - 10.1021/bc060387g

M3 - Article

SN - 1520-4812

VL - 18

SP - 1749

EP - 1755

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

ER -

Wheat germ agglutinin-modified trifunctional nanospheres fo cell recognition

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

3D POROUS CRYSTALS OF TRANS METAL OX: 3D POROUS CRYSTALS OF TRANSITION

Cite this

Wheat germ agglutinin-modified trifunctional nanospheres fo cell recognition

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Projects

3D POROUS CRYSTALS OF TRANS METAL OX: 3D POROUS CRYSTALS OF TRANSITION

Cite this