Wheat germ agglutinin-modified trifunctional nanospheres fo cell recognition

H. Xie, M. Xie, Z. Zhang, Y. Long, X. Liu, M. Tang, D. Pang, Z. Tan, Calum Dickinson, Wuzong Zhou

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

A simple and convenient strategy has been Put forward to fabricate smart fluorescent magnetic wheat germ agglutinin-modified trifunctional nanospheres (WGA-TFNS) for recognition of human prostate carcinoma DU-145 cells which are surface-expressed with sialic acid and N-acetylglucosamine. These TFNS can be easily manipulated, tracked, and conveniently used to capture and separate target cells. The presence of wheat germ agglutinin on the surface of WGA-TFNS was confirmed by FTIR, biorecognition of carboxymethyl chitin-modified quantum dots (CM-CT-QDs), and bacterium Staphylococcus aureus. The success in recognizing DU-145 cells by the WGA-TFNS indicates that WGA-TFNS could be applicable.

Original languageEnglish
Pages (from-to)1749-1755
Number of pages7
JournalBioconjugate Chemistry
Volume18
DOIs
Publication statusPublished - Nov 2007

Keywords

  • QUANTUM DOTS
  • CANCER-CELLS
  • SEMICONDUCTOR NANOCRYSTALS
  • PLGA NANOPARTICLES
  • GENOMIC DNA
  • MAGNETITE
  • LECTIN
  • NANOCOMPOSITES
  • TECHNOLOGY
  • PARTICLES

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