Well-defined, air-stable (NHC)Pd(Allyl)Cl (NHC = N-heterocyclic carbene) catalysts for the arylation of ketones

M S  Viciu; R F  Germaneau; Steven Patrick Nolan

doi:10.1021/ol026745m

Well-defined, air-stable (NHC)Pd(Allyl)Cl (NHC = N-heterocyclic carbene) catalysts for the arylation of ketones

M S Viciu, R F Germaneau, Steven Patrick Nolan

Research output: Contribution to journal › Article › peer-review

263 Citations (Scopus)

Abstract

[GRAPHICS]

A number of palladium-N-heterocyclic carbene (NHC) complexes were found to be active catalysts for the arylation of ketones. A large number of substrates, both aryl halides and ketones, are compatible with the reaction conditions. The ketone arylation reactions are achieved with low catalyst loading in short reaction times using aryl chlorides and triflates; as reactive partners.

Original language	English
Pages (from-to)	4053-4056
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	23
DOIs	https://doi.org/10.1021/ol026745m
Publication status	Published - 14 Nov 2002

Keywords

CROSS-COUPLING REACTIONS
ALPHA-ARYLATION
ARYL CHLORIDES
COMPLEXES
CHEMISTRY
HALIDES
SYSTEM
ACIDS

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10.1021/ol026745m

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title = "Well-defined, air-stable (NHC)Pd(Allyl)Cl (NHC = N-heterocyclic carbene) catalysts for the arylation of ketones",

abstract = "[GRAPHICS]A number of palladium-N-heterocyclic carbene (NHC) complexes were found to be active catalysts for the arylation of ketones. A large number of substrates, both aryl halides and ketones, are compatible with the reaction conditions. The ketone arylation reactions are achieved with low catalyst loading in short reaction times using aryl chlorides and triflates; as reactive partners.",

keywords = "CROSS-COUPLING REACTIONS, ALPHA-ARYLATION, ARYL CHLORIDES, COMPLEXES, CHEMISTRY, HALIDES, SYSTEM, ACIDS",

author = "Viciu, {M S} and Germaneau, {R F} and Nolan, {Steven Patrick}",

year = "2002",

month = nov,

day = "14",

doi = "10.1021/ol026745m",

language = "English",

volume = "4",

pages = "4053--4056",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society (ACS)",

number = "23",

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TY - JOUR

T1 - Well-defined, air-stable (NHC)Pd(Allyl)Cl (NHC = N-heterocyclic carbene) catalysts for the arylation of ketones

AU - Viciu, M S

AU - Germaneau, R F

AU - Nolan, Steven Patrick

PY - 2002/11/14

Y1 - 2002/11/14

N2 - [GRAPHICS]A number of palladium-N-heterocyclic carbene (NHC) complexes were found to be active catalysts for the arylation of ketones. A large number of substrates, both aryl halides and ketones, are compatible with the reaction conditions. The ketone arylation reactions are achieved with low catalyst loading in short reaction times using aryl chlorides and triflates; as reactive partners.

AB - [GRAPHICS]A number of palladium-N-heterocyclic carbene (NHC) complexes were found to be active catalysts for the arylation of ketones. A large number of substrates, both aryl halides and ketones, are compatible with the reaction conditions. The ketone arylation reactions are achieved with low catalyst loading in short reaction times using aryl chlorides and triflates; as reactive partners.

KW - CROSS-COUPLING REACTIONS

KW - ALPHA-ARYLATION

KW - ARYL CHLORIDES

KW - COMPLEXES

KW - CHEMISTRY

KW - HALIDES

KW - SYSTEM

KW - ACIDS

U2 - 10.1021/ol026745m

DO - 10.1021/ol026745m

M3 - Article

SN - 1523-7060

VL - 4

SP - 4053

EP - 4056

JO - Organic Letters

JF - Organic Letters

IS - 23

ER -

Well-defined, air-stable (NHC)Pd(Allyl)Cl (NHC = N-heterocyclic carbene) catalysts for the arylation of ketones

Abstract

Keywords

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