Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Ivan Gusachenko; Mingzhou Chen; Kishan Dholakia

doi:10.1117/12.2274974

Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Ivan Gusachenko, Mingzhou Chen, Kishan Dholakia

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Raman spectroscopy is a valuable tool for non-invasive and label-free identification of sample chemical composition. Recently a few miniaturized optical probes emerged driven by the need to address areas of difficult access, such as in endoscopy. However, imaging modality is still out of reach for most of them. Separately, recent advances in wavefront shaping enabled different microscopies to be applied in various complex media including multimode fibers. Here we present the first and thinnest to date Raman fiber imaging probe based on wavefront shaping through a single multimode fiber without use of any additional optics. We image agglomerates of bacteria and pharmaceuticals to demonstrate the capability of our method. This work paves the way towards compact and flexible Raman endoscopy. © (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Original language	English
Title of host publication	Biomedical Imaging and Sensing Conference
Editors	T. Yatagai, Y. Aizu, O. Matoba, Y. Awatsuji
Publisher	SPIE
Number of pages	3
ISBN (Electronic)	9781510610033
DOIs	https://doi.org/10.1117/12.2274974
Publication status	Published - 18 Apr 2017
Event	3rd Biomedical Imaging and Sensing Conference - Yokohama, Japan Duration: 19 Apr 2017 → 21 Apr 2017

Publication series

Name	Proceedings of SPIE
Publisher	SPIE-Int Soc Optical Engineering
Volume	10251
ISSN (Print)	0277-786X

Conference

Conference	3rd Biomedical Imaging and Sensing Conference
Country/Territory	Japan
City	Yokohama
Period	19/04/17 → 21/04/17

Keywords

Adaptive optics
Raman imaging, optical trapping
Raman spectroscopy
Wavefront correction

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10.1117/12.2274974

Gusachenko-2017-Wavefront-corrrection-SPIE-1025104
© 2017, SPIE. This work has been made available online in accordance with the publisher’s policies. This is the final published version of the work, which was originally published at proceedings.spiedigitallibrary.org / https://doi.org/10.1117/12.2274974
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title = "Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes",

abstract = "Raman spectroscopy is a valuable tool for non-invasive and label-free identification of sample chemical composition. Recently a few miniaturized optical probes emerged driven by the need to address areas of difficult access, such as in endoscopy. However, imaging modality is still out of reach for most of them. Separately, recent advances in wavefront shaping enabled different microscopies to be applied in various complex media including multimode fibers. Here we present the first and thinnest to date Raman fiber imaging probe based on wavefront shaping through a single multimode fiber without use of any additional optics. We image agglomerates of bacteria and pharmaceuticals to demonstrate the capability of our method. This work paves the way towards compact and flexible Raman endoscopy. {\textcopyright} (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.",

keywords = "Adaptive optics, Raman imaging, optical trapping, Raman spectroscopy, Wavefront correction",

author = "Ivan Gusachenko and Mingzhou Chen and Kishan Dholakia",

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Gusachenko, I, Chen, M & Dholakia, K 2017, Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes. in T Yatagai, Y Aizu, O Matoba & Y Awatsuji (eds), Biomedical Imaging and Sensing Conference., 1025104, Proceedings of SPIE, vol. 10251, SPIE, 3rd Biomedical Imaging and Sensing Conference, Yokohama, Japan, 19/04/17. https://doi.org/10.1117/12.2274974

Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes. / Gusachenko, Ivan; Chen, Mingzhou; Dholakia, Kishan.
Biomedical Imaging and Sensing Conference. ed. / T. Yatagai; Y. Aizu; O. Matoba; Y. Awatsuji. SPIE, 2017. 1025104 (Proceedings of SPIE; Vol. 10251).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

AU - Gusachenko, Ivan

AU - Chen, Mingzhou

AU - Dholakia, Kishan

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Y1 - 2017/4/18

N2 - Raman spectroscopy is a valuable tool for non-invasive and label-free identification of sample chemical composition. Recently a few miniaturized optical probes emerged driven by the need to address areas of difficult access, such as in endoscopy. However, imaging modality is still out of reach for most of them. Separately, recent advances in wavefront shaping enabled different microscopies to be applied in various complex media including multimode fibers. Here we present the first and thinnest to date Raman fiber imaging probe based on wavefront shaping through a single multimode fiber without use of any additional optics. We image agglomerates of bacteria and pharmaceuticals to demonstrate the capability of our method. This work paves the way towards compact and flexible Raman endoscopy. © (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

AB - Raman spectroscopy is a valuable tool for non-invasive and label-free identification of sample chemical composition. Recently a few miniaturized optical probes emerged driven by the need to address areas of difficult access, such as in endoscopy. However, imaging modality is still out of reach for most of them. Separately, recent advances in wavefront shaping enabled different microscopies to be applied in various complex media including multimode fibers. Here we present the first and thinnest to date Raman fiber imaging probe based on wavefront shaping through a single multimode fiber without use of any additional optics. We image agglomerates of bacteria and pharmaceuticals to demonstrate the capability of our method. This work paves the way towards compact and flexible Raman endoscopy. © (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

KW - Adaptive optics

KW - Raman imaging, optical trapping

KW - Raman spectroscopy

KW - Wavefront correction

U2 - 10.1117/12.2274974

DO - 10.1117/12.2274974

M3 - Conference contribution

T3 - Proceedings of SPIE

BT - Biomedical Imaging and Sensing Conference

A2 - Yatagai, T.

A2 - Aizu, Y.

A2 - Matoba, O.

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PB - SPIE

T2 - 3rd Biomedical Imaging and Sensing Conference

Y2 - 19 April 2017 through 21 April 2017

ER -

Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Abstract

Publication series

Conference

Keywords

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