Voltage-dependent block by histrionicotoxin of the acetylcholine-induced current in an insect motoneurone cell body

D. B. Satelle; J. A. David

doi:10.1016/0304-3940(83)90125-8

Voltage-dependent block by histrionicotoxin of the acetylcholine-induced current in an insect motoneurone cell body

D. B. Satelle^*, J. A. David

^*Corresponding author for this work

School of Biology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Acetylcholine (ACh)-induced currents were recorded from the voltage-clamped cell body of the fast coxal depressor motoneurone of the cockroach Periplaneta americana, at membrane potentials in the range -120 mV to -60 mV. In the presence of histrionicotoxin (HTX) (1.0 × 10^-6 M), ACh currents were blocked. The blocking action of HTX was voltage-dependent, being more negative membrane potentials.

Original language	English
Pages (from-to)	37-41
Number of pages	5
Journal	Neuroscience Letters
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(83)90125-8
Publication status	Published - 23 Dec 1983

Keywords

acetylcholine-induced current
histrionicotoxin
insect motoneurone
voltage-dependent antagonism

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10.1016/0304-3940(83)90125-8

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abstract = "Acetylcholine (ACh)-induced currents were recorded from the voltage-clamped cell body of the fast coxal depressor motoneurone of the cockroach Periplaneta americana, at membrane potentials in the range -120 mV to -60 mV. In the presence of histrionicotoxin (HTX) (1.0 × 10-6 M), ACh currents were blocked. The blocking action of HTX was voltage-dependent, being more negative membrane potentials.",

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AU - Satelle, D. B.

AU - David, J. A.

PY - 1983/12/23

Y1 - 1983/12/23

N2 - Acetylcholine (ACh)-induced currents were recorded from the voltage-clamped cell body of the fast coxal depressor motoneurone of the cockroach Periplaneta americana, at membrane potentials in the range -120 mV to -60 mV. In the presence of histrionicotoxin (HTX) (1.0 × 10-6 M), ACh currents were blocked. The blocking action of HTX was voltage-dependent, being more negative membrane potentials.

AB - Acetylcholine (ACh)-induced currents were recorded from the voltage-clamped cell body of the fast coxal depressor motoneurone of the cockroach Periplaneta americana, at membrane potentials in the range -120 mV to -60 mV. In the presence of histrionicotoxin (HTX) (1.0 × 10-6 M), ACh currents were blocked. The blocking action of HTX was voltage-dependent, being more negative membrane potentials.

KW - acetylcholine-induced current

KW - histrionicotoxin

KW - insect motoneurone

KW - voltage-dependent antagonism

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Voltage-dependent block by histrionicotoxin of the acetylcholine-induced current in an insect motoneurone cell body

Abstract

Keywords

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