Visible light-promoted iron-catalyzed C(sp2)-C(sp3) Kumada cross-coupling in flow

Xiao-Jing Wei, Irini Abdiaj, Carlo Sambiagio, Chenfei Li, Eli Zysman-Colman, Jesús Alcázar, Timothy Noël

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)
6 Downloads (Pure)

Abstract

A continuous‐flow, visible‐light‐promoted method has been developed to overcome the limitations of iron‐catalyzed Kumada–Corriu cross‐coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron‐catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application.
Original languageEnglish
Pages (from-to)13030-13034
Number of pages6
JournalAngewandte Chemie International Edition
Volume58
Issue number37
Early online date11 Jul 2019
DOIs
Publication statusPublished - 5 Sept 2019

Keywords

  • Cross-coupling
  • Iron catalysis
  • Photocatalysis
  • Kumada coupling
  • Flow chemistry

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