Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii.

F Raible, K Tessmar-Raible, K Osoegawa, P Wincker, C Jubin, G Balavoine, David Ellard Keith Ferrier, V Benes, P de Jong, J Weissenbach, P Bork, D Arendt

Research output: Contribution to journalArticlepeer-review

168 Citations (Scopus)

Abstract

Previous genome comparisons have suggested that one important trend in vertebrate evolution has been a sharp rise in intron abundance. By using genomic data and expressed sequence tags from the marine annelid Platynereis dumerilii, we provide direct evidence that about two-thirds of human introns predate the bilaterian radiation but were lost from insect and nematode genomes to a large extent. A comparison of coding exon sequences confirms the ancestral nature of Platynereis and human genes. Thus, the urbilaterian ancestor had complex, intron-rich genes that have been retained in Platynereis and human.

Original languageEnglish
Pages (from-to)1325-1326
Number of pages2
JournalScience
Volume310
Issue number5752
DOIs
Publication statusPublished - 25 Nov 2005

Keywords

  • CIONA-INTESTINALIS
  • EVOLUTION
  • CONSERVATION
  • ARTHROPODS
  • CHORDATE
  • ANIMALS
  • GENOME
  • PAX-6

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