Ventx family and its functional similarities with Nanog: involvement in embryonic development and cancer progression

Shiv Kumar, Vijay Kumar, Wenchang Li, Jaebong Kim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

The Ventx family is one of the subfamilies of the ANTP (antennapedia) superfamily andbelongs to the NK-like (NKL) subclass. The Ventx family is a homeobox transcription factor and has a DNA-interacting domain evolutionarily conserved throughout vertebrates. It has been extensively studied in Xenopus, zebrafish, and human. The Ventx family contains transcriptional repressors widely involved in embryonic development and tumorigenesis in vertebrates. Several studies have documented that the Ventx family inhibited dorsal mesodermal formation, neural induction, and head formation in Xenopus and zebrafish. Moreover, Ventx2.2 showed functional similarities to Nanog and Barx1, leading to pluripotency and neural-crest migration in vertebrates. Among them, Ventx protein is an orthologue of the Ventx family in humans. Studies have demonstrated that human Ventx was strongly associated with myeloid-cell differentiation and acute myeloid leukemia.The therapeutic potential of Ventx family inhibition in combating cancer progression in humans is discussed. Additionally, we briefly discuss genome evolution, gene duplication, pseudo-allotetraploidy, and the homeobox family in Xenopus.
Original languageEnglish
Article number2741
Number of pages26
JournalInternational Journal of Molecular Sciences
Volume23
Issue number5
DOIs
Publication statusPublished - 1 Mar 2022

Keywords

  • Xenopus
  • Zebrafish
  • Embryonic development
  • Homeobox Nanog
  • Genome evolution
  • Tumorigenesis
  • Ventx family

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