Vaccine and antibody production in plants: developments and computational tools

Kashyap Kumar Dubey, Garry A. Luke, Caroline Knox, Punit Kumar, Brett I. Pletschke, Puneet Kumar Singh, Pratyoosh Shukla

Research output: Contribution to journalReview articlepeer-review

53 Citations (Scopus)
1 Downloads (Pure)

Abstract

Plants as bioreactors have been widely used to express efficient vaccine antigens against viral, bacterial and protozoan infections. To date, many different plant-based expression systems have been analyzed, with a growing preference for transient expression systems. Antibody expression in diverse plant species for therapeutic applications is well known, and this review provides an overview of various aspects of plant-based biopharmaceutical production. Here, we highlight conventional and gene expression technologies in plants along with some illustrative examples. In addition, the portfolio of products that are being produced and how they relate to the success of this field are discussed. Stable and transient gene expression in plants, agrofiltration and virus infection vectors are also reviewed. Further, the present report draws attention to antibody epitope prediction using computational tools, one of the crucial steps of vaccine design. Finally, regulatory issues, biosafety and public perception of this technology are also discussed.
Original languageEnglish
Pages (from-to)295-307
Number of pages14
JournalBriefings in Functional Genomics
Volume17
Issue number5
Early online date5 Jul 2018
DOIs
Publication statusPublished - Sept 2018

Keywords

  • Epitope prediction
  • Computational tools
  • Genetic engineering
  • Plantibody
  • Edible vaccine

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