Abstract
Plants as bioreactors have been widely used to express efficient vaccine antigens against viral, bacterial and protozoan infections. To date, many different plant-based expression systems have been analyzed, with a growing preference for transient expression systems. Antibody expression in diverse plant species for therapeutic applications is well known, and this review provides an overview of various aspects of plant-based biopharmaceutical production. Here, we highlight conventional and gene expression technologies in plants along with some illustrative examples. In addition, the portfolio of products that are being produced and how they relate to the success of this field are discussed. Stable and transient gene expression in plants, agrofiltration and virus infection vectors are also reviewed. Further, the present report draws attention to antibody epitope prediction using computational tools, one of the crucial steps of vaccine design. Finally, regulatory issues, biosafety and public perception of this technology are also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 295-307 |
| Number of pages | 14 |
| Journal | Briefings in Functional Genomics |
| Volume | 17 |
| Issue number | 5 |
| Early online date | 5 Jul 2018 |
| DOIs | |
| Publication status | Published - Sept 2018 |
Keywords
- Epitope prediction
- Computational tools
- Genetic engineering
- Plantibody
- Edible vaccine
Access to Document
- Dubey-2018-Vaccine-and-Ab-BFG-AAM
© 2018, Publisher / the Author(s). This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at www.XXXX.xxx / https://doi.org/xxxx