Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems

Kayla G Barnes, Joshua I Levy, Jillian Gauld, Jonathan Rigby, Oscar Kanjerwa, Christopher B Uzzell, Chisomo Chilupsya, Catherine Anscombe, Christopher Tomkins-Tinch, Omar Mbeti, Edward Cairns, Herbert Thole, Shannon McSweeney, Marah G Chibwana, Philip M Ashton, Khuzwayo C Jere, John Scott Meschke, Peter Diggle, Jennifer Cornick, Benjamin ChilimaKondwani Jambo, Kristian G Andersen, Gift Kawalazira, Steve Paterson, Tonney S Nyirenda, Nicholas Feasey

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
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Abstract

The COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance has been critical for pandemic control, however not all countries can currently sustain community pathogen surveillance programs. Wastewater surveillance has proven valuable in high-income settings, but less is known about the utility of water surveillance of pathogens in low-income countries. Here we show how wastewater surveillance of SAR-CoV-2 can be used to identify temporal changes and help determine circulating variants quickly. In Malawi, a country with limited community-based COVID-19 testing capacity, we explore the utility of rivers and wastewater for SARS-CoV-2 surveillance. From May 2020-May 2022, we collect water from up to 112 river or defunct wastewater treatment plant sites, detecting SARS-CoV-2 in 8.3% of samples. Peak SARS-CoV-2 detection in water samples predate peaks in clinical cases. Sequencing of water samples identified the Beta, Delta, and Omicron variants, with Delta and Omicron detected well in advance of detection in patients. Our work highlights how wastewater can be used to detect emerging waves, identify variants of concern, and provide an early warning system in settings with no formal sewage systems.
Original languageEnglish
Article number7883
Number of pages11
JournalNature Communications
Volume14
DOIs
Publication statusPublished - 30 Nov 2023

Keywords

  • Humans
  • Water
  • Rivers
  • Sewage
  • Pandemics
  • Wastewater-based epidemiological monitoring
  • COVID-19
  • SARS-CoV-2
  • COVID-19 testing
  • Wastewater

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