Utilising proteomic approaches to understand oncogenic human herpesviruses (Review)

Christopher B Owen, David J Hughes, Belinda Baquero-Perez, Anja Berndt, Sophie Schumann, Brian R Jackson, Adrian Whitehouse

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Abstract

The γ-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are successful pathogens, each infecting a large proportion of the human population. These viruses persist for the life of the host and may each contribute to a number of malignancies, for which there are currently no cures. Large-scale proteomic-based approaches provide an excellent means of increasing the collective understanding of the proteomes of these complex viruses and elucidating their numerous interactions within the infected host cell. These large-scale studies are important for the identification of the intricacies of viral infection and the development of novel therapeutics against these two important pathogens.
Original languageEnglish
Pages (from-to)891-903
Number of pages13
JournalMolecular and Clinical Oncology
Volume2
Issue number6
Early online date9 Jul 2014
DOIs
Publication statusPublished - Nov 2014

Keywords

  • Proteomics
  • Mass spectrometry
  • Gamma-herpesvirus

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