Abstract
The rational design of a bis(phosphine oxide) host which is capable of binding a benzylic amine is presented. The ability of this host to increase the rate of addition of 4-fluorobenzylamine to N-phenylmaleimide is rationalized in terms of the enhancement of the nucleophilicity of the benzylic amine.
Original language | English |
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Volume | 2 |
Publication status | Published - 18 May 2000 |
Keywords
- BISPHOSPHONATE RECEPTOR MOLECULES
- DIELS-ALDER REACTIONS
- BIOCHEMICAL PATHWAYS
- ARTIFICIAL ENZYMES
- CATALYSIS
- ACCELERATION
- RECOGNITION
- MIMICS
- MODELS