Update on the diagnosis of tuberculosis

Irina Kontsevaya*, Andrea Maurizio Cabibbe, Daniela Maria Cirillo, Andrew R DiNardo, Nicole Frahm, Stephen Henry Gillespie, David Holtzman, Lennard Meiwes, Elisa Petruccioli, Maja Reimann, Morten Ruhwald, Wilber Sabiiti, Francesca Saluzzo, Elisa Tagliani, Delia Goletti

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)
8 Downloads (Pure)

Abstract

Background
Tuberculosis remains a global public health threat, and the development of rapid and precise diagnostic tools is the key to enabling the early start of treatment, monitoring response to treatment, and preventing the spread of the disease.

Objective
An overview of recent progress in host- and pathogen-based tuberculosis diagnostics.

Sources
We conducted a PubMed search of recent relevant articles and guidelines on tuberculosis screening and diagnosis.

Content
An overview of currently used methods and perspectives in the following areas of tuberculosis diagnostics is provided: immune-based diagnostics, X-ray, clinical symptoms and scores, cough detection, culture of Mycobacterium tuberculosis and identifying its resistance profile using phenotypic and genotypic methods, including next generation sequencing, sputum- and non-sputum-based molecular diagnosis of tuberculosis and monitoring of response to treatment.

Implications
A brief overview of the most relevant advances and changes in international guidelines regarding screening and diagnosing tuberculosis is provided in this review. It aims at reviewing all relevant areas of diagnostics, including both pathogen- and host-based methods.
Original languageEnglish
JournalClinical Microbiology and Infection
VolumeIn Press
Early online date18 Jul 2023
DOIs
Publication statusE-pub ahead of print - 18 Jul 2023

Keywords

  • Tuberculosis
  • Diagnosis
  • Biomarkers

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