Unexpected triaxial preferences in some all-syn 1,3,5-trifluorocyclohexanes

Cihang Yu, Bruno A. Piscelli, Nawaf Al Maharik, David B. Cordes, Alexandra M. Z. Slawin, Rodrigo A. Cormanich*, David O'Hagan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
4 Downloads (Pure)

Abstract

Theory and solution NMR indicate that all-syn 1,3,5-trifluorocyclohexane 5 adopts the expected tri-equatorial conformation, however in the solid state the more polar triaxial conformation is observed. This and the favoured conformations of substituted (Me, OMe, NH(CO)Me, NHBoc) derivatives of 5 are investigated to explore triaxial C–F preferences.
Original languageEnglish
Pages (from-to)12855-12858
Number of pages4
JournalChemical Communications
Volume58
Issue number92
Early online date25 Oct 2022
DOIs
Publication statusPublished - 28 Nov 2022

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