TY - JOUR
T1 - Understanding the rise of the superbug
T2 - Investigation of the evolution and genomic variation of Staphylococcus aureus
AU - Lindsay, Jodi A.
AU - Holden, Matthew T.G.
PY - 2006/7
Y1 - 2006/7
N2 - The bacterium Staphylococcus aureus is a common cause of human infection, and it is becoming increasingly virulent and resistant to antibiotics. Our understanding of the evolution of this species has been greatly enhanced by the recent sequencing of the genomes of seven strains of S. aureus. Comparative genomic analysis allows us to identify variation in the chromosomes and understand the mechanisms by which this versatile bacterium has accumulated diversity within its genome structure.
AB - The bacterium Staphylococcus aureus is a common cause of human infection, and it is becoming increasingly virulent and resistant to antibiotics. Our understanding of the evolution of this species has been greatly enhanced by the recent sequencing of the genomes of seven strains of S. aureus. Comparative genomic analysis allows us to identify variation in the chromosomes and understand the mechanisms by which this versatile bacterium has accumulated diversity within its genome structure.
KW - Mobile genetic elements
KW - Resistance
KW - Staphylococcus aureus
KW - Virulence
UR - http://www.scopus.com/inward/record.url?scp=33745081753&partnerID=8YFLogxK
U2 - 10.1007/s10142-005-0019-7
DO - 10.1007/s10142-005-0019-7
M3 - Review article
C2 - 16453141
AN - SCOPUS:33745081753
SN - 1438-793X
VL - 6
SP - 186
EP - 201
JO - Functional and Integrative Genomics
JF - Functional and Integrative Genomics
IS - 3
ER -