Tuning the Nitric Oxide release from CPO-27 MOFs

Damiano Cattaneo; Stewart James Warrender; Morven Jane Duncan; Christopher Kelsall; Mary Doherty; Phillip Whitfield; Ian Megson; Russell Edward Morris

doi:10.1039/C5RA24023A

Tuning the Nitric Oxide release from CPO-27 MOFs

Damiano Cattaneo, Stewart James Warrender, Morven Jane Duncan, Christopher Kelsall, Mary Doherty, Phillip Whitfield, Ian Megson, Russell Edward Morris

Research output: Contribution to journal › Article › peer-review

Abstract

Nitric Oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications.

Original language	English
Pages (from-to)	14059-14067
Journal	RSC Advances
Volume	6
Issue number	17
Early online date	26 Jan 2016
DOIs	https://doi.org/10.1039/C5RA24023A
Publication status	Published - 2016

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10.1039/C5RA24023ALicence: CC BY

Morris_2015_RSCA_Tuning_CCBY
Copyright 2016 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
Final published version, 2.6 MBLicence: CC BY

Assembly Disassembly Reassembly: Assembly disassembly reassembly - New routes to extended structures and their impact
Morris, R. E. (PI)
EPSRC
1/08/13 → 31/07/18
Project: Fellowship

Data underpinning - Tuning the Nitric Oxide Release from CPO-27 MOFs
Cattaneo, D. (Creator), Warrender, S. J. (Creator), Duncan, M. J. (Creator), Kelsall, C. J. (Creator), Doherty, M. K. (Creator), Whitfield, P. D. (Creator), Megson, I. L. (Creator) & Morris, R. E. (Creator), University of St Andrews, 2016
DOI: 10.17630/2F275963-7FA4-4AD9-8B60-B6BCCEC76CAC
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title = "Tuning the Nitric Oxide release from CPO-27 MOFs",

abstract = "Nitric Oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications.",

author = "Damiano Cattaneo and Warrender, {Stewart James} and Duncan, {Morven Jane} and Christopher Kelsall and Mary Doherty and Phillip Whitfield and Ian Megson and Morris, {Russell Edward}",

note = "The authors gratefully acknowledge the funding of this work from Scottish Enterprise (POC13), the EPSRC (EP/K025112/1), the British Heart Foundation (NH/11/8/29253) and the Royal Society (Brian Mercer Award for Innovation - MI120033). Date of Acceptance: 17/01/2016",

year = "2016",

doi = "10.1039/C5RA24023A",

language = "English",

volume = "6",

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T1 - Tuning the Nitric Oxide release from CPO-27 MOFs

AU - Cattaneo, Damiano

AU - Warrender, Stewart James

AU - Duncan, Morven Jane

AU - Kelsall, Christopher

AU - Doherty, Mary

AU - Whitfield, Phillip

AU - Megson, Ian

AU - Morris, Russell Edward

N1 - The authors gratefully acknowledge the funding of this work from Scottish Enterprise (POC13), the EPSRC (EP/K025112/1), the British Heart Foundation (NH/11/8/29253) and the Royal Society (Brian Mercer Award for Innovation - MI120033). Date of Acceptance: 17/01/2016

PY - 2016

Y1 - 2016

N2 - Nitric Oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications.

AB - Nitric Oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications.

U2 - 10.1039/C5RA24023A

DO - 10.1039/C5RA24023A

M3 - Article

SN - 2046-2069

VL - 6

SP - 14059

EP - 14067

JO - RSC Advances

JF - RSC Advances

IS - 17

ER -

Tuning the Nitric Oxide release from CPO-27 MOFs

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Assembly Disassembly Reassembly: Assembly disassembly reassembly - New routes to extended structures and their impact

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Data underpinning - Tuning the Nitric Oxide Release from CPO-27 MOFs

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