Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

Alan R. Burns; Jennifer H. Kerr; William J. Kerr; Joanna Passmore; Laura C. Paterson; Allan J. B. Watson

doi:10.1039/c001772h

Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

Alan R. Burns, Jennifer H. Kerr, William J. Kerr, Joanna Passmore, Laura C. Paterson, Allan J. B. Watson

School of Chemistry

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Abstract

The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.

Original language	English
Pages (from-to)	2777-2783
Number of pages	7
Journal	Organic & Biomolecular Chemistry
Volume	8
Issue number	12
DOIs	https://doi.org/10.1039/c001772h
Publication status	Published - 2010

Keywords

tuned methods
organic chemistry
vinyl oxadiazole
synthesis
pharmacology

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title = "Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs",

abstract = "The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.",

keywords = "tuned methods, organic chemistry, vinyl oxadiazole, synthesis, pharmacology",

author = "Burns, \{Alan R.\} and Kerr, \{Jennifer H.\} and Kerr, \{William J.\} and Joanna Passmore and Paterson, \{Laura C.\} and Watson, \{Allan J. B.\}",

year = "2010",

doi = "10.1039/c001772h",

language = "English",

volume = "8",

pages = "2777--2783",

journal = "Organic \& Biomolecular Chemistry",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

AU - Burns, Alan R.

AU - Kerr, Jennifer H.

AU - Kerr, William J.

AU - Passmore, Joanna

AU - Paterson, Laura C.

AU - Watson, Allan J. B.

PY - 2010

Y1 - 2010

N2 - The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.

AB - The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.

KW - tuned methods

KW - organic chemistry

KW - vinyl oxadiazole

KW - synthesis

KW - pharmacology

UR - https://www.scopus.com/pages/publications/77953176832

U2 - 10.1039/c001772h

DO - 10.1039/c001772h

M3 - Article

SN - 1477-0520

VL - 8

SP - 2777

EP - 2783

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 12

ER -

Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

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