Tuberculosis Molecular Bacterial Load Assay reveals early delayed bacterial killing in patients with relapse

Nyanda Elias Ntinginya, Abishek Bakuli, Daniel Mapamba, Wilber Sabiiti, Gibson Kibiki, Lilian Tina Minja, Davis Kuchaka, Klaus Reither, Patrick Phillips, Martin J Boeree, Stephen Henry Gillespie, Michael Hoelscher, Norbert Heinrich*, PanACEA Consortium

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.
Original languageEnglish
Article numberciac445
Pages (from-to)e990-e994
Number of pages5
JournalClinical Infectious Diseases
Volume76
Issue number3
Early online date19 Jun 2022
DOIs
Publication statusPublished - 1 Feb 2023

Keywords

  • Tuberculosis
  • Biomarker
  • Relapse
  • Clinical trial

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