Tuberculosis molecular bacterial load assay in the management of tuberculosis

Stephen H Gillespie; Wilber Sabiiti

doi:10.1097/QCO.0000000000001084

Tuberculosis molecular bacterial load assay in the management of tuberculosis

Stephen H Gillespie^*, Wilber Sabiiti

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose of review: Treatment monitoring remains a challenge in tuberculosis. The development of the tuberculosis molecular bacterial load assay (TB-MBLA) opens the possibility of real-time treatment monitoring. This review summarizes recent TB-MBLA research and outlines a future research agenda.

Recent findings: Recent studies show that TB-MBLA can be applied a wide range of specimens to make a quantitative assessment of the number live M. tuberculosis organisms rapidly. This allows real-time monitoring of treatment response that simplifies patient management and facilitates comparison of different treatment regimens.

Summary: The ability to measure the number of live organisms in real-time could improve treatment outcome. The TB-MBLA should revolutionize our understanding of the pathology of tuberculosis with significant implications for clinical practice and research.

Original language	English
Pages (from-to)	176-181
Journal	Current Opinion in Infectious Diseases
Volume	38
Issue number	2
Early online date	18 Dec 2024
DOIs	https://doi.org/10.1097/QCO.0000000000001084
Publication status	Published - Apr 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/QCO.0000000000001084

Cite this

@article{31f2d407d7bb45c29a8390532703fd74,

title = "Tuberculosis molecular bacterial load assay in the management of tuberculosis",

abstract = "Purpose of review: Treatment monitoring remains a challenge in tuberculosis. The development of the tuberculosis molecular bacterial load assay (TB-MBLA) opens the possibility of real-time treatment monitoring. This review summarizes recent TB-MBLA research and outlines a future research agenda.Recent findings: Recent studies show that TB-MBLA can be applied a wide range of specimens to make a quantitative assessment of the number live M. tuberculosis organisms rapidly. This allows real-time monitoring of treatment response that simplifies patient management and facilitates comparison of different treatment regimens.Summary: The ability to measure the number of live organisms in real-time could improve treatment outcome. The TB-MBLA should revolutionize our understanding of the pathology of tuberculosis with significant implications for clinical practice and research.",

author = "Gillespie, {Stephen H} and Wilber Sabiiti",

year = "2025",

month = apr,

doi = "10.1097/QCO.0000000000001084",

language = "English",

volume = "38",

pages = "176--181",

journal = "Current Opinion in Infectious Diseases",

issn = "0951-7375",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Tuberculosis molecular bacterial load assay in the management of tuberculosis

AU - Gillespie, Stephen H

AU - Sabiiti, Wilber

PY - 2025/4

Y1 - 2025/4

N2 - Purpose of review: Treatment monitoring remains a challenge in tuberculosis. The development of the tuberculosis molecular bacterial load assay (TB-MBLA) opens the possibility of real-time treatment monitoring. This review summarizes recent TB-MBLA research and outlines a future research agenda.Recent findings: Recent studies show that TB-MBLA can be applied a wide range of specimens to make a quantitative assessment of the number live M. tuberculosis organisms rapidly. This allows real-time monitoring of treatment response that simplifies patient management and facilitates comparison of different treatment regimens.Summary: The ability to measure the number of live organisms in real-time could improve treatment outcome. The TB-MBLA should revolutionize our understanding of the pathology of tuberculosis with significant implications for clinical practice and research.

AB - Purpose of review: Treatment monitoring remains a challenge in tuberculosis. The development of the tuberculosis molecular bacterial load assay (TB-MBLA) opens the possibility of real-time treatment monitoring. This review summarizes recent TB-MBLA research and outlines a future research agenda.Recent findings: Recent studies show that TB-MBLA can be applied a wide range of specimens to make a quantitative assessment of the number live M. tuberculosis organisms rapidly. This allows real-time monitoring of treatment response that simplifies patient management and facilitates comparison of different treatment regimens.Summary: The ability to measure the number of live organisms in real-time could improve treatment outcome. The TB-MBLA should revolutionize our understanding of the pathology of tuberculosis with significant implications for clinical practice and research.

U2 - 10.1097/QCO.0000000000001084

DO - 10.1097/QCO.0000000000001084

M3 - Article

C2 - 39705386

SN - 0951-7375

VL - 38

SP - 176

EP - 181

JO - Current Opinion in Infectious Diseases

JF - Current Opinion in Infectious Diseases

IS - 2

ER -

Tuberculosis molecular bacterial load assay in the management of tuberculosis

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this