Tuberculosis molecular bacterial load assay in the management of tuberculosis

Stephen H Gillespie; Wilber Sabiiti

doi:10.1097/QCO.0000000000001084

Tuberculosis molecular bacterial load assay in the management of tuberculosis

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE OF REVIEW: Treatment monitoring remains a challenge in tuberculosis. The development of the tuberculosis molecular bacterial load assay (TB-MBLA) opens the possibility of real-time treatment monitoring. This review summarizes recent TB-MBLA research and outlines a future research agenda.

RECENT FINDINGS: Recent studies show that TB-MBLA can be applied a wide range of specimens to make a quantitative assessment of the number live M. tuberculosis organisms rapidly. This allows real-time monitoring of treatment response that simplifies patient management and facilitates comparison of different treatment regimens.

SUMMARY: The ability to measure the number of live organisms in real-time could improve treatment outcome. The TB-MBLA should revolutionize our understanding of the pathology of tuberculosis with significant implications for clinical practice and research.

Original language	English
Journal	Current Opinion in Infectious Diseases
DOIs	https://doi.org/10.1097/QCO.0000000000001084
Publication status	E-pub ahead of print - 18 Dec 2024

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abstract = "PURPOSE OF REVIEW: Treatment monitoring remains a challenge in tuberculosis. The development of the tuberculosis molecular bacterial load assay (TB-MBLA) opens the possibility of real-time treatment monitoring. This review summarizes recent TB-MBLA research and outlines a future research agenda.RECENT FINDINGS: Recent studies show that TB-MBLA can be applied a wide range of specimens to make a quantitative assessment of the number live M. tuberculosis organisms rapidly. This allows real-time monitoring of treatment response that simplifies patient management and facilitates comparison of different treatment regimens.SUMMARY: The ability to measure the number of live organisms in real-time could improve treatment outcome. The TB-MBLA should revolutionize our understanding of the pathology of tuberculosis with significant implications for clinical practice and research.",

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AU - Sabiiti, Wilber

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AB - PURPOSE OF REVIEW: Treatment monitoring remains a challenge in tuberculosis. The development of the tuberculosis molecular bacterial load assay (TB-MBLA) opens the possibility of real-time treatment monitoring. This review summarizes recent TB-MBLA research and outlines a future research agenda.RECENT FINDINGS: Recent studies show that TB-MBLA can be applied a wide range of specimens to make a quantitative assessment of the number live M. tuberculosis organisms rapidly. This allows real-time monitoring of treatment response that simplifies patient management and facilitates comparison of different treatment regimens.SUMMARY: The ability to measure the number of live organisms in real-time could improve treatment outcome. The TB-MBLA should revolutionize our understanding of the pathology of tuberculosis with significant implications for clinical practice and research.

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JF - Current Opinion in Infectious Diseases

ER -

Tuberculosis molecular bacterial load assay in the management of tuberculosis

Abstract

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