Abstract
Infection leads to competition between the virus and the host-cell for translational resources. Taken together, viruses have evolved an extraordinarily wide range of mechanisms to modify or inhibit every stage of the host-cell translational process, thereby supressing the translation of host-cell mRNAs whilst enhancing translation of their own mRNAs. Indeed, in many cases (host-cell) mRNA cap-dependent translation can be completely ‘shut-off’ whilst virus mRNAs are translated in a cap-independent manner. Sequestration of translational resources serves not only to increase the yield of virus particles, but also supressing the host-cell immune responses.
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of virology |
| Subtitle of host publication | Volume 1 The virus as a concept - Fundamentals of virology |
| Editors | Dennis H. Bamford, Mark Zuckerman |
| Place of Publication | New York |
| Publisher | Academic Press/Elsevier |
| Pages | 444-459 |
| Number of pages | 16 |
| Edition | 4th |
| ISBN (Electronic) | 9780128145166 |
| ISBN (Print) | 9780128145159 |
| DOIs | |
| Publication status | Published - 1 Mar 2021 |
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