Translation of viral proteins

Martin Denis Ryan; Garry Alec Luke

doi:10.1016/B978-0-12-814515-9.00119-3

Translation of viral proteins

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Infection leads to competition between the virus and the host-cell for translational resources. Taken together, viruses have evolved an extraordinarily wide range of mechanisms to modify or inhibit every stage of the host-cell translational process, thereby supressing the translation of host-cell mRNAs whilst enhancing translation of their own mRNAs. Indeed, in many cases (host-cell) mRNA cap-dependent translation can be completely ‘shut-off’ whilst virus mRNAs are translated in a cap-independent manner. Sequestration of translational resources serves not only to increase the yield of virus particles, but also supressing the host-cell immune responses.

Original language	English
Title of host publication	Encyclopedia of virology
Subtitle of host publication	Volume 1 The virus as a concept - Fundamentals of virology
Editors	Dennis H. Bamford, Mark Zuckerman
Place of Publication	New York
Publisher	Academic Press/Elsevier
Pages	444-459
Number of pages	16
Edition	4th
ISBN (Electronic)	9780128145166
ISBN (Print)	9780128145159
DOIs	https://doi.org/10.1016/B978-0-12-814515-9.00119-3
Publication status	Published - 1 Mar 2021

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10.1016/B978-0-12-814515-9.00119-3

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Translation of viral proteins

Abstract

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