Translation of viral proteins

Martin Denis Ryan, Garry Alec Luke

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Infection leads to competition between the virus and the host-cell for translational resources. Taken together, viruses have evolved an extraordinarily wide range of mechanisms to modify or inhibit every stage of the host-cell translational process, thereby supressing the translation of host-cell mRNAs whilst enhancing translation of their own mRNAs. Indeed, in many cases (host-cell) mRNA cap-dependent translation can be completely ‘shut-off’ whilst virus mRNAs are translated in a cap-independent manner. Sequestration of translational resources serves not only to increase the yield of virus particles, but also supressing the host-cell immune responses.
Original languageEnglish
Title of host publicationEncyclopedia of virology
Subtitle of host publicationVolume 1 The virus as a concept - Fundamentals of virology
EditorsDennis H. Bamford, Mark Zuckerman
Place of PublicationNew York
PublisherAcademic Press/Elsevier
Pages444-459
Number of pages16
Edition4th
ISBN (Electronic)9780128145166
ISBN (Print)9780128145159
DOIs
Publication statusPublished - 1 Mar 2021

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