Transfusion-transmitted malaria: a systematic review and meta-analysis

Ehsan Ahmadpour; Masoud Foroutan-Rad; Hamidreza Majidiani; Sirous Mehrani Moghaddam; Kareem Hatam-Nahavandi; Seyed-Abdollah Hosseini; Mohammad Taghi Rahimi; Aleksandra Barac; Salvatore Rubino; Mehdi Zarean; Alexander G Mathioudakis; Muge Cevik

doi:10.1093/ofid/ofz283

Transfusion-transmitted malaria: a systematic review and meta-analysis

Ehsan Ahmadpour, Masoud Foroutan-Rad, Hamidreza Majidiani, Sirous Mehrani Moghaddam, Kareem Hatam-Nahavandi, Seyed-Abdollah Hosseini, Mohammad Taghi Rahimi, Aleksandra Barac, Salvatore Rubino, Mehdi Zarean, Alexander G Mathioudakis, Muge Cevik

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature.

Methods: PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to October 10, 2017. All peer-reviewed original research articles describing the prevalence of malaria parasitemia in blood donors with different diagnostic methods were included. The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I² index and Cochran's Q test. Publication and population bias was assessed with funnel plots and Egger's regression asymmetry test. All statistical analyses were performed using Stata (version 2.7.2).

Results: Seventy-one studies from 21 countries, 5 continents, were included in the present systematic review. The median prevalence of malaria parasitemia among 984 975 asymptomatic healthy blood donors was 10.54%, 5.36%, and 0.38% by microscopy, molecular methods (polymerase chain reaction), and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum.

Conclusions: This systematic review demonstrates that compared with other transfusion-linked infections, that is, HIV, HCV, and HBV, transfusion-transmitted malaria is one of the most significant transfusion-associated infections especially in Sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malaria-endemic settings.

Original language	English
Article number	ofz283
Number of pages	8
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	7
Early online date	11 Jun 2019
DOIs	https://doi.org/10.1093/ofid/ofz283
Publication status	Published - Jul 2019

Keywords

Blood donor
Plasmodium
Systematic review
Transfusion-associated infections
Transfusion medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/ofid/ofz283Licence: CC BY-NC-ND

Ahmadpour-2019-Transfusion-OFID-ofz283-CC
© The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [email protected]
Final published version, 448 KBLicence: CC BY-NC-ND

1 Comment/debate

Corrigendum to: Transfusion-transmitted malaria: a systematic review and meta-analysis (Open Forum Infectious Diseases (2019) 6:7 (ofz283) DOI: 10.1093/ofid/ofz283)
Ahmadpour, E., Foroutan-Rad, M., Majidiani, H., Moghaddam, S. M., Hatam-Nahavandi, K., Hosseini, S.-A., Rahimi, M. T., Barac, A., Rubino, S., Zarean, M., Mathioudakis, A. G. & Cevik, M., Jan 2020, In: Open Forum Infectious Diseases. 7, 1, 1 p., ofz540.
Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Cite this

@article{046992a0ed064d3996c5af6dfc2b0368,

title = "Transfusion-transmitted malaria: a systematic review and meta-analysis",

abstract = "Background: Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature.Methods: PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to October 10, 2017. All peer-reviewed original research articles describing the prevalence of malaria parasitemia in blood donors with different diagnostic methods were included. The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I2 index and Cochran's Q test. Publication and population bias was assessed with funnel plots and Egger's regression asymmetry test. All statistical analyses were performed using Stata (version 2.7.2).Results: Seventy-one studies from 21 countries, 5 continents, were included in the present systematic review. The median prevalence of malaria parasitemia among 984 975 asymptomatic healthy blood donors was 10.54%, 5.36%, and 0.38% by microscopy, molecular methods (polymerase chain reaction), and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum.Conclusions: This systematic review demonstrates that compared with other transfusion-linked infections, that is, HIV, HCV, and HBV, transfusion-transmitted malaria is one of the most significant transfusion-associated infections especially in Sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malaria-endemic settings.",

keywords = "Blood donor, Plasmodium, Systematic review, Transfusion-associated infections, Transfusion medicine",

author = "Ehsan Ahmadpour and Masoud Foroutan-Rad and Hamidreza Majidiani and Moghaddam, {Sirous Mehrani} and Kareem Hatam-Nahavandi and Seyed-Abdollah Hosseini and Rahimi, {Mohammad Taghi} and Aleksandra Barac and Salvatore Rubino and Mehdi Zarean and Mathioudakis, {Alexander G} and Muge Cevik",

year = "2019",

month = jul,

doi = "10.1093/ofid/ofz283",

language = "English",

volume = "6",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Transfusion-transmitted malaria

T2 - a systematic review and meta-analysis

AU - Ahmadpour, Ehsan

AU - Foroutan-Rad, Masoud

AU - Majidiani, Hamidreza

AU - Moghaddam, Sirous Mehrani

AU - Hatam-Nahavandi, Kareem

AU - Hosseini, Seyed-Abdollah

AU - Rahimi, Mohammad Taghi

AU - Barac, Aleksandra

AU - Rubino, Salvatore

AU - Zarean, Mehdi

AU - Mathioudakis, Alexander G

AU - Cevik, Muge

PY - 2019/7

Y1 - 2019/7

N2 - Background: Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature.Methods: PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to October 10, 2017. All peer-reviewed original research articles describing the prevalence of malaria parasitemia in blood donors with different diagnostic methods were included. The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I2 index and Cochran's Q test. Publication and population bias was assessed with funnel plots and Egger's regression asymmetry test. All statistical analyses were performed using Stata (version 2.7.2).Results: Seventy-one studies from 21 countries, 5 continents, were included in the present systematic review. The median prevalence of malaria parasitemia among 984 975 asymptomatic healthy blood donors was 10.54%, 5.36%, and 0.38% by microscopy, molecular methods (polymerase chain reaction), and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum.Conclusions: This systematic review demonstrates that compared with other transfusion-linked infections, that is, HIV, HCV, and HBV, transfusion-transmitted malaria is one of the most significant transfusion-associated infections especially in Sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malaria-endemic settings.

AB - Background: Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature.Methods: PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to October 10, 2017. All peer-reviewed original research articles describing the prevalence of malaria parasitemia in blood donors with different diagnostic methods were included. The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I2 index and Cochran's Q test. Publication and population bias was assessed with funnel plots and Egger's regression asymmetry test. All statistical analyses were performed using Stata (version 2.7.2).Results: Seventy-one studies from 21 countries, 5 continents, were included in the present systematic review. The median prevalence of malaria parasitemia among 984 975 asymptomatic healthy blood donors was 10.54%, 5.36%, and 0.38% by microscopy, molecular methods (polymerase chain reaction), and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum.Conclusions: This systematic review demonstrates that compared with other transfusion-linked infections, that is, HIV, HCV, and HBV, transfusion-transmitted malaria is one of the most significant transfusion-associated infections especially in Sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malaria-endemic settings.

KW - Blood donor

KW - Plasmodium

KW - Systematic review

KW - Transfusion-associated infections

KW - Transfusion medicine

U2 - 10.1093/ofid/ofz283

DO - 10.1093/ofid/ofz283

M3 - Article

C2 - 31334300

SN - 2328-8957

VL - 6

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 7

M1 - ofz283

ER -

Transfusion-transmitted malaria: a systematic review and meta-analysis

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Research output

Corrigendum to: Transfusion-transmitted malaria: a systematic review and meta-analysis (Open Forum Infectious Diseases (2019) 6:7 (ofz283) DOI: 10.1093/ofid/ofz283)

Cite this