Trajectory-based co-localization measures for nanoparticle-cell interaction studies

Juan A Varela, Christoffer Åberg, Jeremy C Simpson, Kenneth A Dawson

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

High-resolution live cell microscopy will soon have a fundamental role in understanding bio-nano interactions, providing material that can be exploited using single particle tracking techniques. The present work uses 3D timelapse images obtained with confocal microscopy, to temporally resolve the co-localization between polystyrene nanoparticles and lysosomes in live cells through object-based measurements.

Original languageEnglish
Pages (from-to)2026-31
Number of pages6
JournalSmall
Volume11
Issue number17
DOIs
Publication statusPublished - 6 May 2015

Keywords

  • Biological Transport
  • Cell Line, Tumor
  • Fluorescent Dyes/chemistry
  • Humans
  • Imaging, Three-Dimensional
  • Lung Neoplasms/metabolism
  • Lysosomes/chemistry
  • Microscopy, Confocal/instrumentation
  • Nanoparticles/chemistry
  • Polystyrenes/chemistry
  • Stochastic Processes
  • Time Factors

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