Towards harmonization of microscopy methods for malaria clinical research studies

Research Malaria Microscopy Working Group, Mehul Dhorda, El Hadji Ba, J. Kevin Baird, John Barnwell, David Bell, Jane Y. Carter, Arjen Dondorp, Lenny Ekawati, Michelle Gatton, Iveth González, Philippe J. Guérin, Sandra Incardona, Ken Lilley, Didier Menard, François Nosten, Peter Obare, Bernhards Ogutu, Piero L. Olliaro, Ric N. PriceStéphane Proux, Andrew R. Ramsay, John C. Reeder, Kamolrat Silamut, Cheikh Sokhna

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Microscopy performed on stained films of peripheral blood for detection, identification and quantification of malaria parasites is an essential reference standard for clinical trials of drugs, vaccines and diagnostic tests for malaria. The value of data from such research is greatly enhanced if this reference standard is consistent across time and geography. Adherence to common standards and practices is a prerequisite to achieve this. The rationale for proposed research standards and procedures for the preparation, staining and microscopic examination of blood films for malaria parasites is presented here with the aim of improving the consistency and reliability of malaria microscopy performed in such studies. These standards constitute the core of a quality management system for clinical research studies employing microscopy as a reference standard. They can be used as the basis for the design of training and proficiency testing programmes as well as for procedures and quality assurance of malaria microscopy in clinical research.
Original languageEnglish
Article number324
Number of pages14
JournalMalaria Journal
Publication statusPublished - 4 Sept 2020


  • Malaria
  • Microscopy
  • Harmonization
  • Clinical research
  • Diagnostic
  • Standard


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