Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones

Ian Paterson, Gordon John Florence, Kai Gerlach, Jeremy P. Scott

Research output: Contribution to journalArticlepeer-review

147 Citations (Scopus)
Original languageEnglish
Pages (from-to)377-380
Number of pages5
JournalAngewandte Chemie International Edition
Volume39
Issue number2
DOIs
Publication statusPublished - 2000

Keywords

  • BETA-HYDROXY KETONES
  • STEREOSELECTIVE SYNTHESIS
  • STEREOCONTROLLED SYNTHESIS
  • MACROLIDE SYNTHESIS
  • IMMUNOSUPPRESSANT DISCODERMOLIDE
  • POLYPROPIONATE SYNTHESIS
  • ACYLATION CATALYSTS
  • SUBUNIT
  • (-)-DISCODERMOLIDE
  • FRAGMENT

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