Time is of the essence for ParaHox homeobox gene clustering.

Myles Grant Garstang, David Ellard Keith Ferrier

Research output: Contribution to journalReview article

15 Citations (Scopus)
4 Downloads (Pure)

Abstract

ParaHox genes, and their evolutionary sisters the Hox genes, are integral to patterning the anterior-posterior axis of most animals. Like the Hox genes, ParaHox genes can be clustered and exhibit the phenomenon of colinearity - gene order within the cluster matching gene activation. Two new instances of ParaHox clustering provide the first examples of intact clusters outside chordates, with gene expression lending weight to the argument that temporal colinearity is the key to understanding clustering.
Original languageEnglish
Article number72
JournalBMC Biology
Volume11
Issue number72
DOIs
Publication statusPublished - Jun 2013

Keywords

  • ParaHox genes
  • Hox gene
  • Colinearity
  • ParaHox clustering

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