Three-dimensional optical coherence microelastography of skeletal muscle tissue

Lixin Chin*, Brendan F. Kennedy, Kelsey M. Kennedy, Philip Wijesinghe, Gavin J. Pinniger, Jessica R. Terrill, Robert A. McLaughlin, David D. Sampson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


In many muscle pathologies, impairment of skeletal muscle function is closely linked to changes in the mechanical properties of the muscle constituents. Optical coherence micro-elastography (OCME) uses optical coherence tomography (OCT) imaging of tissue under a quasi-static, compressive mechanical load to map variations in tissue mechanical properties on the micro-scale. We present the first study of OCME on skeletal muscle tissue. We show that this technique can resolve features of muscle tissue including fibers, fascicles and tendon, and can also detect necrotic lesions in skeletal muscle from the mdx mouse model of Duchenne muscular dystrophy. In many instances, OCME provides better or additional contrast complementary to that provided by OCT. These results suggest that OCME could provide new understanding and opportunity for assessment of skeletal muscle pathologies.

Original languageEnglish
Article numberA3090
Pages (from-to)3090-3102
Number of pages13
JournalBiomedical Optics Express
Issue number9
Publication statusPublished - 1 Sept 2014


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