A construct that works both above and below the nation, region is often an implied rather than explicit critical framework in cinema and media studies. This In Focus dossier mobilizes post-millennial Southeast Asian film and video cultures to conceptualize the place of region in the field. Across five essays, contributors theorize region as both a supranational space of collectivity and a subnational sphere of minoritarian and indigenous film practices. What kinds of networks can regional thinking engender? What histories does it unearth, and which might it obscure? How have states, industries, and institutions enabled or obstructed these exchanges? In what ways might parallel themes, aesthetics, and modes of production and circulation constitute a regional cinema? With these questions as a starting point, the essays cover a wide range of topics and approaches: filmmaking within contexts of authoritarianism, trans-regionalist aesthetics, industry studies, and ecocinema studies.