The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis

Kate J Howell, Lucy A Weinert, Roy R Chaudhuri, Shi-Lu Luan, Sarah E Peters, Jukka Corander, David Harris, Øystein Angen, Virginia Aragon, Albert Bensaid, Susanna M Williamson, Julian Parkhill, Paul R Langford, Andrew N Rycroft, Brendan W Wren, Matthew T Holden, Alexander W Tucker, Duncan J Maskell

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)
1 Downloads (Pure)

Abstract

Haemophilus parasuis is the etiologic agent of Glasser's disease in pigs and causes devastating losses to the farming industry. Whilst some hyper-virulent isolates have been described, the relationship between genetics and disease outcome has been only partially established. In particular, there is weak correlation between serovar and disease phenotype. We sequenced the genomes of 212 isolates of H. parasuis and have used this to describe the pan-genome and to correlate this with clinical and carrier status, as well as with serotype.
Original languageEnglish
Article number1179
JournalBMC Genomics
Volume15
DOIs
Publication statusPublished - 24 Dec 2014

Keywords

  • Genome wide association study
  • Pan-genome
  • Recombination
  • DAPC
  • Virulence factors
  • Population structure
  • Haemophilus parasuis

Fingerprint

Dive into the research topics of 'The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis'. Together they form a unique fingerprint.

Cite this