The synthesis of multiply C-13-labelled plant and mammalian lignans as internal standards for LC-MS and GC-MS analysis

T Fryatt, N P Botting

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The syntheses of multiply C-13-labelled derivatives of the two mammalian lignans, enterolactone and enterodiol, and two of their plant lignan precursors, secoisolariciresinol and matairesinol, are described. Three C-13 atoms were incorporated into each lignan using potassium [C-13]cyanide as the source for all of the C-13 atoms. The compounds were prepared for use as internal standards in the LC-MS and GC-MS analysis of lignans. Copyright (c) 2005 John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)951-969
Number of pages19
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume48
DOIs
Publication statusPublished - Nov 2005

Keywords

  • lignans
  • phytoestrogens
  • enterolactone
  • enterodiol
  • analysis
  • <H-2>-LABELED URINARY LIGNANS
  • MASS-SPECTROMETRY
  • BREAST-CANCER
  • SERUM CONCENTRATIONS
  • ENTEROLACTONE
  • RISK
  • QUANTIFICATION
  • PHYTOESTROGENS
  • IDENTIFICATION
  • ISOFLAVONOIDS

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