The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides

Angel A. Nunez; Graham R. Eastham; David J. Cole-Hamilton

doi:10.1039/b706635j

The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides

Angel A. Nunez, Graham R. Eastham, David J. Cole-Hamilton

Research output: Contribution to journal › Article › peer-review

Abstract

Amides can be hydrogenated to amines using a catalyst prepared in situ from [Ru(acac)(3)] and 1,1,1- tris(diphenylphosphinomethyl) ethane; water is required to stabilize the catalyst and primary amines can only be formed (selectivity up to 85%) if ammonia is also present.

Original language	English
Pages (from-to)	3154-3156
Number of pages	3
Journal	Chemical Communications
Issue number	30
DOIs	https://doi.org/10.1039/b706635j
Publication status	Published - 2007

Keywords

RUTHENIUM-CATALYZED HYDROGENATION
DIMETHYL OXALATE
LIGANDS
ESTERS

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10.1039/b706635j

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title = "The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides",

abstract = "Amides can be hydrogenated to amines using a catalyst prepared in situ from [Ru(acac)(3)] and 1,1,1- tris(diphenylphosphinomethyl) ethane; water is required to stabilize the catalyst and primary amines can only be formed (selectivity up to 85%) if ammonia is also present.",

keywords = "RUTHENIUM-CATALYZED HYDROGENATION, DIMETHYL OXALATE, LIGANDS, ESTERS",

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doi = "10.1039/b706635j",

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journal = "Chemical Communications",

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AU - Eastham, Graham R.

AU - Cole-Hamilton, David J.

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N2 - Amides can be hydrogenated to amines using a catalyst prepared in situ from [Ru(acac)(3)] and 1,1,1- tris(diphenylphosphinomethyl) ethane; water is required to stabilize the catalyst and primary amines can only be formed (selectivity up to 85%) if ammonia is also present.

AB - Amides can be hydrogenated to amines using a catalyst prepared in situ from [Ru(acac)(3)] and 1,1,1- tris(diphenylphosphinomethyl) ethane; water is required to stabilize the catalyst and primary amines can only be formed (selectivity up to 85%) if ammonia is also present.

KW - RUTHENIUM-CATALYZED HYDROGENATION

KW - DIMETHYL OXALATE

KW - LIGANDS

KW - ESTERS

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DO - 10.1039/b706635j

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SP - 3154

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JO - Chemical Communications

JF - Chemical Communications

IS - 30

ER -

The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides

Abstract

Keywords

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