The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides

Angel A. Nunez, Graham R. Eastham, David J. Cole-Hamilton

Research output: Contribution to journalArticlepeer-review

128 Citations (Scopus)

Abstract

Amides can be hydrogenated to amines using a catalyst prepared in situ from [Ru(acac)(3)] and 1,1,1- tris(diphenylphosphinomethyl) ethane; water is required to stabilize the catalyst and primary amines can only be formed (selectivity up to 85%) if ammonia is also present.

Original languageEnglish
Pages (from-to)3154-3156
Number of pages3
JournalChemical Communications
Issue number30
DOIs
Publication statusPublished - 2007

Keywords

  • RUTHENIUM-CATALYZED HYDROGENATION
  • DIMETHYL OXALATE
  • LIGANDS
  • ESTERS

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