The synthesis of 1-fluoro- and 1,1,-difluoro- analogues of 1-deoxy-D-xylulose

D Bouvet; David O'Hagan

The synthesis of 1-fluoro- and 1,1,-difluoro- analogues of 1-deoxy-D-xylulose

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Abstract

1-Deoxy-D-xylulose is a key intermediate in bacterial co-factor biosynthesis. We report the synthesis of the 1-fluoro- and 1,1-difluoro- analogues of 1-deoxy-D-xylulose as potential antimetabolites of bacterial 1-deoxy-D-xylulose metabolism (C) 1999 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	10481 - 10486
Number of pages	6
Journal	Tetrahedron
Volume	55
Publication status	Published - 20 Aug 1999

Keywords

NON-MEVALONATE PATHWAY
ESCHERICHIA-COLI
BIOSYNTHESIS
ISOPRENOIDS
THIAZOLE
ENZYMES

Cite this

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title = "The synthesis of 1-fluoro- and 1,1,-difluoro- analogues of 1-deoxy-D-xylulose",

abstract = "1-Deoxy-D-xylulose is a key intermediate in bacterial co-factor biosynthesis. We report the synthesis of the 1-fluoro- and 1,1-difluoro- analogues of 1-deoxy-D-xylulose as potential antimetabolites of bacterial 1-deoxy-D-xylulose metabolism (C) 1999 Elsevier Science Ltd. All rights reserved.",

keywords = "NON-MEVALONATE PATHWAY, ESCHERICHIA-COLI, BIOSYNTHESIS, ISOPRENOIDS, THIAZOLE, ENZYMES",

author = "D Bouvet and David O'Hagan",

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month = aug,

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pages = "10481 -- 10486",

journal = "Tetrahedron",

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AU - Bouvet, D

AU - O'Hagan, David

PY - 1999/8/20

Y1 - 1999/8/20

N2 - 1-Deoxy-D-xylulose is a key intermediate in bacterial co-factor biosynthesis. We report the synthesis of the 1-fluoro- and 1,1-difluoro- analogues of 1-deoxy-D-xylulose as potential antimetabolites of bacterial 1-deoxy-D-xylulose metabolism (C) 1999 Elsevier Science Ltd. All rights reserved.

AB - 1-Deoxy-D-xylulose is a key intermediate in bacterial co-factor biosynthesis. We report the synthesis of the 1-fluoro- and 1,1-difluoro- analogues of 1-deoxy-D-xylulose as potential antimetabolites of bacterial 1-deoxy-D-xylulose metabolism (C) 1999 Elsevier Science Ltd. All rights reserved.

KW - NON-MEVALONATE PATHWAY

KW - ESCHERICHIA-COLI

KW - BIOSYNTHESIS

KW - ISOPRENOIDS

KW - THIAZOLE

KW - ENZYMES

UR - https://www.scopus.com/pages/publications/0033588318

M3 - Article

SN - 0040-4020

VL - 55

SP - 10481

EP - 10486

JO - Tetrahedron

JF - Tetrahedron

ER -

The synthesis of 1-fluoro- and 1,1,-difluoro- analogues of 1-deoxy-D-xylulose

Abstract

Keywords

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