The synthesis of 1-fluoro- and 1,1,-difluoro- analogues of 1-deoxy-D-xylulose

D Bouvet, David O'Hagan

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

1-Deoxy-D-xylulose is a key intermediate in bacterial co-factor biosynthesis. We report the synthesis of the 1-fluoro- and 1,1-difluoro- analogues of 1-deoxy-D-xylulose as potential antimetabolites of bacterial 1-deoxy-D-xylulose metabolism (C) 1999 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)10481 - 10486
Number of pages6
JournalTetrahedron
Volume55
Publication statusPublished - 20 Aug 1999

Keywords

  • NON-MEVALONATE PATHWAY
  • ESCHERICHIA-COLI
  • BIOSYNTHESIS
  • ISOPRENOIDS
  • THIAZOLE
  • ENZYMES

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