The synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate

Davide Bello; Tashfeen Aslam; G Bultynck; Alexandra Martha Zoya Slawin; H L Roderick; M D Bootman; Stuart John Conway

doi:10.1021/jo070611a

The synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate

Davide Bello, Tashfeen Aslam, G Bultynck, Alexandra Martha Zoya Slawin, H L Roderick, M D Bootman, Stuart John Conway

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonists or antagonists.

Original language	English
Pages (from-to)	5647-5659
Number of pages	13
Journal	The Journal of Organic Chemistry
Volume	72
Issue number	15
Early online date	22 Jun 2007
DOIs	https://doi.org/10.1021/jo070611a
Publication status	Published - 20 Jul 2007

Keywords

2-AMINOETHOXYDIPHENYL BORATE 2-APB
ADENOPHOSTIN-A
MYOINOSITOL 1,4,5-TRISPHOSPHATE
TRISPHOSPHATE RECEPTORS
XESTOSPONGIN-C
PENICILLIUM-BREVICOMPACTUM
EXPEDITIOUS ROUTE
POTENT INHIBITOR
CALCIUM-RELEASE
CA2+ PUMPS

Access to Document

10.1021/jo070611a

Cite this

@article{f03a0ad067b24ae0b2e5a0d9df54d8d7,

title = "The synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate",

abstract = "The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonists or antagonists.",

keywords = "2-AMINOETHOXYDIPHENYL BORATE 2-APB, ADENOPHOSTIN-A, MYOINOSITOL 1,4,5-TRISPHOSPHATE, TRISPHOSPHATE RECEPTORS, XESTOSPONGIN-C, PENICILLIUM-BREVICOMPACTUM, EXPEDITIOUS ROUTE, POTENT INHIBITOR, CALCIUM-RELEASE, CA2+ PUMPS",

author = "Davide Bello and Tashfeen Aslam and G Bultynck and Slawin, {Alexandra Martha Zoya} and Roderick, {H L} and Bootman, {M D} and Conway, {Stuart John}",

year = "2007",

month = jul,

day = "20",

doi = "10.1021/jo070611a",

language = "English",

volume = "72",

pages = "5647--5659",

journal = "The Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society (ACS)",

number = "15",

}

TY - JOUR

T1 - The synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate

AU - Bello, Davide

AU - Aslam, Tashfeen

AU - Bultynck, G

AU - Slawin, Alexandra Martha Zoya

AU - Roderick, H L

AU - Bootman, M D

AU - Conway, Stuart John

PY - 2007/7/20

Y1 - 2007/7/20

N2 - The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonists or antagonists.

AB - The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonists or antagonists.

KW - 2-AMINOETHOXYDIPHENYL BORATE 2-APB

KW - ADENOPHOSTIN-A

KW - MYOINOSITOL 1,4,5-TRISPHOSPHATE

KW - TRISPHOSPHATE RECEPTORS

KW - XESTOSPONGIN-C

KW - PENICILLIUM-BREVICOMPACTUM

KW - EXPEDITIOUS ROUTE

KW - POTENT INHIBITOR

KW - CALCIUM-RELEASE

KW - CA2+ PUMPS

UR - http://www.scopus.com/inward/record.url?scp=34547103735&partnerID=8YFLogxK

U2 - 10.1021/jo070611a

DO - 10.1021/jo070611a

M3 - Article

SN - 0022-3263

VL - 72

SP - 5647

EP - 5659

JO - The Journal of Organic Chemistry

JF - The Journal of Organic Chemistry

IS - 15

ER -

The synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

BB/C515255/1: A Reverse chemical genetics and chemical biology approach to probing 1,4,5-trisphosphate receptor function

Cite this

The synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

BB/C515255/1: A Reverse chemical genetics and chemical biology approach to probing 1,4,5-trisphosphate receptor function

Cite this