The Suzuki-Miyaura reaction performed using a palladium-N-Heterocyclic carbene catalyst and a weak inorganic base

Frederic Izquierdo, Martin Michel Alfred Eton Corpet, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)
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Abstract

N-Heterocyclic carbenes (NHCs) have been shown to be useful ligands for the Suzuki-Miyaura cross-coupling at low catalyst loadings. We now report that the commercially available and air-stable [Pd(IPr)(cin)Cl] pre-catalyst permits the formation of various functionalized biaryls from aryl chlorides and boronic acids (37 examples) under very mild conditions using a mixture of ethanol/water as solvent and an inorganic base.
Original languageEnglish
Pages (from-to)1920-1924
Number of pages5
JournalEuropean Journal of Organic Chemistry
Early online date18 Feb 2015
DOIs
Publication statusPublished - 2015

Keywords

  • Catalysis
  • Cross-coupling
  • NHC
  • Palladium
  • Suzuki-Miyaura

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