The Streptococcus equi prophage-encoded protein SEQ2045 is a hyaluronan-specific hyaluronate lyase that is produced during equine infection

Anna-Marie Lindsay, Meng Zhang, Zoe Mitchell, Matthew T. G. Holden, Andrew S. Waller, Iain C. Sutcliffe, Gary W. Black*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Streptococcus equi causes equine 'strangles'. Hyaluronate lyases, which degrade connective tissue hyaluronan and chondroitins, are thought to facilitate streptococcal invasion of the host. However, prophage-encoded hyaluronate lyases are hyaluronan-specific and are thought to be primarily involved in the degradation of the hyaluronan capsule of streptococci during bacteriophage infection. To understand the role of prophage-encoded hyaluronate lyases further, we have biochemically characterized such a hyaluronate lyase, SEQ2045 from S. equi, and have shown that it is produced during equine infection. Prophage-encoded hyaluronan-specific hyaluronate lyases may therefore play a more direct role in disease pathogenesis than previously thought.

Original languageEnglish
Pages (from-to)443-449
Number of pages7
JournalMicrobiology
Volume155
Issue number2
DOIs
Publication statusPublished - Feb 2009

Keywords

  • GROUP-A
  • BACTERIOPHAGE HYALURONIDASE
  • MOLECULAR-BASIS
  • PYOGENES
  • PHAGE
  • VIRULENCE
  • SEQUENCE
  • GENE
  • STRANGLES
  • SULFATE

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