The role of TET-mediated DNA hydroxymethylation in prostate cancer

E. Smeets, A. G. Lynch, S. Prekovic, T. Van den Broeck, L Moris, C. Helsen, S. Joniau, F. Claessens, C. E. Massie

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)
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Abstract

Ten-eleven translocation (TET) proteins are recently characterized dioxygenases that regulate demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine and further derivatives. The recent finding that 5hmC is also a stable and independent epigenetic modification indicates that these proteins play an important role in diverse physiological and pathological processes such as neural and tumor development. Both the genomic distribution of (hydroxy)methylation and the expression and activity of TET proteins are dysregulated in a wide range of cancers including prostate cancer. Up to now it is still unknown how changes in TET and 5(h)mC profiles are related to the pathogenesis of prostate cancer. In this review, we explore recent advances in the current understanding of how TET expression and function are regulated in development and cancer. Furthermore, we look at the impact on 5hmC in prostate cancer and the potential underlying mechanisms. Finally, we tried to summarize the latest techniques for detecting and quantifying global and locus-specific 5hmC levels of genomic DNA.

Original languageEnglish
Pages (from-to)41-55
JournalMolecular and Cellular Endocrinology
Volume462
Issue numberA
Early online date1 Sept 2017
DOIs
Publication statusPublished - 15 Feb 2018

Keywords

  • Prostate cancer
  • Epigenetics
  • TET
  • DNA hydroxymethylation
  • 5hmC

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