The rhamnose pathway

MF Giraud; James Henderson Naismith

The rhamnose pathway

MF Giraud, James Henderson Naismith

Research output: Other contribution

190 Citations (Scopus)

Abstract

L-Rhamnose is a deoxy sugar found widely in bacteria and plants. Evidence continues to emerge about its essential role in many pathogenic bacteria. The crystal structures of two of the four enzymes involved in its biosynthetic pathway have been reported and the other two have been submitted for publication. This pathway does not exist in humans, making enzymes of this pathway very attractive targets for therapeutic intervention.

Original language	English
Volume	10
Publication status	Published - Dec 2000

Keywords

UDP-GALACTOSE 4-EPIMERASE
GDP-FUCOSE SYNTHETASE
ESCHERICHIA-COLI
PSEUDOMONAS-AERUGINOSA
GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
KANAMYCIN NUCLEOTIDYLTRANSFERASE
GENE-CLUSTER
BIOSYNTHESIS
IDENTIFICATION
SITE

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title = "The rhamnose pathway",

abstract = "L-Rhamnose is a deoxy sugar found widely in bacteria and plants. Evidence continues to emerge about its essential role in many pathogenic bacteria. The crystal structures of two of the four enzymes involved in its biosynthetic pathway have been reported and the other two have been submitted for publication. This pathway does not exist in humans, making enzymes of this pathway very attractive targets for therapeutic intervention.",

keywords = "UDP-GALACTOSE 4-EPIMERASE, GDP-FUCOSE SYNTHETASE, ESCHERICHIA-COLI, PSEUDOMONAS-AERUGINOSA, GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE, KANAMYCIN NUCLEOTIDYLTRANSFERASE, GENE-CLUSTER, BIOSYNTHESIS, IDENTIFICATION, SITE",

author = "MF Giraud and Naismith, {James Henderson}",

note = "Curr Opin Struc Biol",

year = "2000",

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T1 - The rhamnose pathway

AU - Giraud, MF

AU - Naismith, James Henderson

N1 - Curr Opin Struc Biol

PY - 2000/12

Y1 - 2000/12

N2 - L-Rhamnose is a deoxy sugar found widely in bacteria and plants. Evidence continues to emerge about its essential role in many pathogenic bacteria. The crystal structures of two of the four enzymes involved in its biosynthetic pathway have been reported and the other two have been submitted for publication. This pathway does not exist in humans, making enzymes of this pathway very attractive targets for therapeutic intervention.

AB - L-Rhamnose is a deoxy sugar found widely in bacteria and plants. Evidence continues to emerge about its essential role in many pathogenic bacteria. The crystal structures of two of the four enzymes involved in its biosynthetic pathway have been reported and the other two have been submitted for publication. This pathway does not exist in humans, making enzymes of this pathway very attractive targets for therapeutic intervention.

KW - UDP-GALACTOSE 4-EPIMERASE

KW - GDP-FUCOSE SYNTHETASE

KW - ESCHERICHIA-COLI

KW - PSEUDOMONAS-AERUGINOSA

KW - GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE

KW - KANAMYCIN NUCLEOTIDYLTRANSFERASE

KW - GENE-CLUSTER

KW - BIOSYNTHESIS

KW - IDENTIFICATION

KW - SITE

UR - http://www.scopus.com/inward/record.url?scp=0034519831&partnerID=8YFLogxK

M3 - Other contribution

VL - 10

ER -

The rhamnose pathway

Abstract

Keywords

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