The relationship between cancer patient's fear of recurrence and radiotherapy: a systematic review and meta-analysis

Yuan Yang; Josie Cameron; Gerry Humphris

doi:10.1002/pon.4224

The relationship between cancer patient's fear of recurrence and radiotherapy: a systematic review and meta-analysis

Yuan Yang
, Josie Cameron
, Gerry Humphris

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

OBJECTIVE: This review aims to provide an overview of the current knowledge available on the nature and extent of the relationship between external-beam radiotherapy (RT) and fear of cancer recurrence (FoR).

METHODS: PubMed, MEDLINE and EMBASE databases were searched to identify relevant studies. Systematic review procedures were followed including a quality assessment. Meta-analysis of suitable studies was conducted.

RESULTS: Twenty-five eligible studies were included in the systematic review and 15 of them were included in further meta-analysis. Meta-analysis of the available data confirmed a weak relationship between RT and FoR (15 studies, 9567 patients, overall r = 0.053, 95%, CI: 0.021-0.085, P = 0.001). Subgroup analysis based on cancer site (breast cancer versus other types of cancer) revealed that the correlation between RT and FoR was statistically significant in 'other cancer' group (P˂0.001) but was nonsignificant in 'breast cancer' group (P = 0.538).

CONCLUSIONS: While meta-analysis reports a statistically significant association between cancer patient's FoR and the receipt of RT, these results should be interpreted with caution due to significant variability between studies. Further longitudinal studies should be conducted to address the trajectory of FoR over RT in greater detail.

Original language	English
Pages (from-to)	738-746
Number of pages	9
Journal	Psycho-Oncology
Volume	26
Issue number	6
Early online date	10 Aug 2016
DOIs	https://doi.org/10.1002/pon.4224
Publication status	Published - Jun 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Radiotherapy
Fear of recurrence
Cancer
Oncology
Meta-analysis

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Humphris_2016_PO_Recurrence_AM
© 2016, John Wiley & Sons Ltd. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at onlinelibrary.wiley.com / https://dx.doi.org/10.1002/pon.4224
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@article{7635d2fa58074d078d77666ffccfef0b,

title = "The relationship between cancer patient's fear of recurrence and radiotherapy: a systematic review and meta-analysis",

abstract = "OBJECTIVE: This review aims to provide an overview of the current knowledge available on the nature and extent of the relationship between external-beam radiotherapy (RT) and fear of cancer recurrence (FoR).METHODS: PubMed, MEDLINE and EMBASE databases were searched to identify relevant studies. Systematic review procedures were followed including a quality assessment. Meta-analysis of suitable studies was conducted.RESULTS: Twenty-five eligible studies were included in the systematic review and 15 of them were included in further meta-analysis. Meta-analysis of the available data confirmed a weak relationship between RT and FoR (15 studies, 9567 patients, overall r = 0.053, 95\%, CI: 0.021-0.085, P = 0.001). Subgroup analysis based on cancer site (breast cancer versus other types of cancer) revealed that the correlation between RT and FoR was statistically significant in 'other cancer' group (P˂0.001) but was nonsignificant in 'breast cancer' group (P = 0.538).CONCLUSIONS: While meta-analysis reports a statistically significant association between cancer patient's FoR and the receipt of RT, these results should be interpreted with caution due to significant variability between studies. Further longitudinal studies should be conducted to address the trajectory of FoR over RT in greater detail. ",

keywords = "Radiotherapy, Fear of recurrence, Cancer, Oncology, Meta-analysis",

author = "Yuan Yang and Josie Cameron and Gerry Humphris",

note = "The authors are also grateful to the Breast Cancer Now for supporting this research (grant reference number 6873).",

year = "2017",

month = jun,

doi = "10.1002/pon.4224",

language = "English",

volume = "26",

pages = "738--746",

journal = "Psycho-Oncology",

issn = "1057-9249",

publisher = "John Wiley \& Sons, Ltd",

number = "6",

}

TY - JOUR

T1 - The relationship between cancer patient's fear of recurrence and radiotherapy

T2 - a systematic review and meta-analysis

AU - Yang, Yuan

AU - Cameron, Josie

AU - Humphris, Gerry

N1 - The authors are also grateful to the Breast Cancer Now for supporting this research (grant reference number 6873).

PY - 2017/6

Y1 - 2017/6

N2 - OBJECTIVE: This review aims to provide an overview of the current knowledge available on the nature and extent of the relationship between external-beam radiotherapy (RT) and fear of cancer recurrence (FoR).METHODS: PubMed, MEDLINE and EMBASE databases were searched to identify relevant studies. Systematic review procedures were followed including a quality assessment. Meta-analysis of suitable studies was conducted.RESULTS: Twenty-five eligible studies were included in the systematic review and 15 of them were included in further meta-analysis. Meta-analysis of the available data confirmed a weak relationship between RT and FoR (15 studies, 9567 patients, overall r = 0.053, 95%, CI: 0.021-0.085, P = 0.001). Subgroup analysis based on cancer site (breast cancer versus other types of cancer) revealed that the correlation between RT and FoR was statistically significant in 'other cancer' group (P˂0.001) but was nonsignificant in 'breast cancer' group (P = 0.538).CONCLUSIONS: While meta-analysis reports a statistically significant association between cancer patient's FoR and the receipt of RT, these results should be interpreted with caution due to significant variability between studies. Further longitudinal studies should be conducted to address the trajectory of FoR over RT in greater detail.

AB - OBJECTIVE: This review aims to provide an overview of the current knowledge available on the nature and extent of the relationship between external-beam radiotherapy (RT) and fear of cancer recurrence (FoR).METHODS: PubMed, MEDLINE and EMBASE databases were searched to identify relevant studies. Systematic review procedures were followed including a quality assessment. Meta-analysis of suitable studies was conducted.RESULTS: Twenty-five eligible studies were included in the systematic review and 15 of them were included in further meta-analysis. Meta-analysis of the available data confirmed a weak relationship between RT and FoR (15 studies, 9567 patients, overall r = 0.053, 95%, CI: 0.021-0.085, P = 0.001). Subgroup analysis based on cancer site (breast cancer versus other types of cancer) revealed that the correlation between RT and FoR was statistically significant in 'other cancer' group (P˂0.001) but was nonsignificant in 'breast cancer' group (P = 0.538).CONCLUSIONS: While meta-analysis reports a statistically significant association between cancer patient's FoR and the receipt of RT, these results should be interpreted with caution due to significant variability between studies. Further longitudinal studies should be conducted to address the trajectory of FoR over RT in greater detail.

KW - Radiotherapy

KW - Fear of recurrence

KW - Cancer

KW - Oncology

KW - Meta-analysis

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U2 - 10.1002/pon.4224

DO - 10.1002/pon.4224

M3 - Review article

C2 - 27419668

SN - 1057-9249

VL - 26

SP - 738

EP - 746

JO - Psycho-Oncology

JF - Psycho-Oncology

IS - 6

ER -

The relationship between cancer patient's fear of recurrence and radiotherapy: a systematic review and meta-analysis

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The relationship between cancer patient's fear of recurrence and radiotherapy: a systematic review and meta-analysis

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