The relationship between cancer patient's fear of recurrence and chemotherapy: a systematic review and meta-analysis

Yuan Yang; Yunhong Wen; Carolyn Bedi; Gerry Humphris

doi:10.1016/j.jpsychores.2017.05.002

The relationship between cancer patient's fear of recurrence and chemotherapy: a systematic review and meta-analysis

Yuan Yang, Yunhong Wen, Carolyn Bedi, Gerry Humphris

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Objective: The study aim was to provide an overview of the current evidence available on the link between chemotherapy (CTX) and fear of cancer recurrence (FoR).
Methods: PubMED, Medline, Embase, PsycINFO and Web of Science databases were searched to identify relevant studies. Two authors independently selected and assessed the studies regarding eligibility criteria. Meta-analysis of suitable studies was conducted, and quality rated.
Results: Forty eligible studies were included in the systematic review and twenty-nine of them were included in further meta-analysis. Meta-analysis of the available data confirmed a weak relationship between CTX and FoR (29 studies, 30,176 patients, overall r = 0.093, 95%, CI: 0.062–0.123, P < 0.001). Conclusions: The meta-analysis demonstrates a weak but significant relationship between cancer patient's FoR and the receipt of chemotherapy. However, these results should be interpreted with caution. Further investigation is warranted to explore possible mechanisms of FoR increase in patients who receive chemotherapy. Longitudinal studies assessing the trajectory of FoR during chemotherapy are also warranted.

Original language	English
Pages (from-to)	55-63
Number of pages	9
Journal	Journal of Psychosomatic Research
Volume	98
Early online date	3 May 2017
DOIs	https://doi.org/10.1016/j.jpsychores.2017.05.002
Publication status	Published - Jul 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chemotherapy
Cancer
Fear of recurrence
Meta-analysis
Oncology
Systematic review

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10.1016/j.jpsychores.2017.05.002Licence: CC BY-NC-ND

Humphris_2017_JPR_Recurrence&Chemotherapy_CC
© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Final published version, 488 KBLicence: CC BY-NC-ND

Cite this

@article{7bd9d975517e4e0ebf1079e5273201bf,

title = "The relationship between cancer patient's fear of recurrence and chemotherapy: a systematic review and meta-analysis",

abstract = "Objective: The study aim was to provide an overview of the current evidence available on the link between chemotherapy (CTX) and fear of cancer recurrence (FoR). Methods: PubMED, Medline, Embase, PsycINFO and Web of Science databases were searched to identify relevant studies. Two authors independently selected and assessed the studies regarding eligibility criteria. Meta-analysis of suitable studies was conducted, and quality rated. Results: Forty eligible studies were included in the systematic review and twenty-nine of them were included in further meta-analysis. Meta-analysis of the available data confirmed a weak relationship between CTX and FoR (29 studies, 30,176 patients, overall r = 0.093, 95\%, CI: 0.062–0.123, P < 0.001). Conclusions: The meta-analysis demonstrates a weak but significant relationship between cancer patient's FoR and the receipt of chemotherapy. However, these results should be interpreted with caution. Further investigation is warranted to explore possible mechanisms of FoR increase in patients who receive chemotherapy. Longitudinal studies assessing the trajectory of FoR during chemotherapy are also warranted.",

keywords = "Chemotherapy, Cancer, Fear of recurrence, Meta-analysis, Oncology, Systematic review",

author = "Yuan Yang and Yunhong Wen and Carolyn Bedi and Gerry Humphris",

note = "This review was funded by Breast Cancer Now (grant number 6873).",

year = "2017",

month = jul,

doi = "10.1016/j.jpsychores.2017.05.002",

language = "English",

volume = "98",

pages = "55--63",

journal = "Journal of Psychosomatic Research",

issn = "0022-3999",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - The relationship between cancer patient's fear of recurrence and chemotherapy

T2 - a systematic review and meta-analysis

AU - Yang, Yuan

AU - Wen, Yunhong

AU - Bedi, Carolyn

AU - Humphris, Gerry

N1 - This review was funded by Breast Cancer Now (grant number 6873).

PY - 2017/7

Y1 - 2017/7

N2 - Objective: The study aim was to provide an overview of the current evidence available on the link between chemotherapy (CTX) and fear of cancer recurrence (FoR). Methods: PubMED, Medline, Embase, PsycINFO and Web of Science databases were searched to identify relevant studies. Two authors independently selected and assessed the studies regarding eligibility criteria. Meta-analysis of suitable studies was conducted, and quality rated. Results: Forty eligible studies were included in the systematic review and twenty-nine of them were included in further meta-analysis. Meta-analysis of the available data confirmed a weak relationship between CTX and FoR (29 studies, 30,176 patients, overall r = 0.093, 95%, CI: 0.062–0.123, P < 0.001). Conclusions: The meta-analysis demonstrates a weak but significant relationship between cancer patient's FoR and the receipt of chemotherapy. However, these results should be interpreted with caution. Further investigation is warranted to explore possible mechanisms of FoR increase in patients who receive chemotherapy. Longitudinal studies assessing the trajectory of FoR during chemotherapy are also warranted.

AB - Objective: The study aim was to provide an overview of the current evidence available on the link between chemotherapy (CTX) and fear of cancer recurrence (FoR). Methods: PubMED, Medline, Embase, PsycINFO and Web of Science databases were searched to identify relevant studies. Two authors independently selected and assessed the studies regarding eligibility criteria. Meta-analysis of suitable studies was conducted, and quality rated. Results: Forty eligible studies were included in the systematic review and twenty-nine of them were included in further meta-analysis. Meta-analysis of the available data confirmed a weak relationship between CTX and FoR (29 studies, 30,176 patients, overall r = 0.093, 95%, CI: 0.062–0.123, P < 0.001). Conclusions: The meta-analysis demonstrates a weak but significant relationship between cancer patient's FoR and the receipt of chemotherapy. However, these results should be interpreted with caution. Further investigation is warranted to explore possible mechanisms of FoR increase in patients who receive chemotherapy. Longitudinal studies assessing the trajectory of FoR during chemotherapy are also warranted.

KW - Chemotherapy

KW - Cancer

KW - Fear of recurrence

KW - Meta-analysis

KW - Oncology

KW - Systematic review

UR - http://www.sciencedirect.com/science/article/pii/S0022399917302192#appd001

UR - https://www.scopus.com/pages/publications/85018881729

U2 - 10.1016/j.jpsychores.2017.05.002

DO - 10.1016/j.jpsychores.2017.05.002

M3 - Review article

SN - 0022-3999

VL - 98

SP - 55

EP - 63

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

ER -

The relationship between cancer patient's fear of recurrence and chemotherapy: a systematic review and meta-analysis

Abstract

UN SDGs

Keywords

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