The regulation of type I interferon production by paramyxoviruses

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71 Citations (Scopus)

Abstract

Experimentally, paramyxoviruses are conventionally considered good inducers of type I interferons (IFN-alpha/beta), and have been used as agents in the commercial production of human IFN-alpha. However, in the last few years it has become clear that viruses in general mount a major challenge to the IFN system, and paramyxoviruses are no exception. Indeed, most paramyxoviruses encode mechanisms to inhibit both the production of, and response to, type I IFN. Here we review our knowledge of the type I IFN-inducing signals (by so-called pathogen-associated molecular patterns, or PAMPs) produced during paramyxovirus infections, and discuss how paramyxoviruses limit the production of PAMPs and inhibit the cellular responses to PAMPs by interfering with the activities of the pattern recognition receptors (PRRs), mda-5, and RIG-I, as well as downstream components in the type I IFN induction cascades.

Original languageEnglish
Pages (from-to)539 - 547
Number of pages9
JournalJournal of Interferon and Cytokine Research
Volume29
Issue number9
DOIs
Publication statusPublished - Sept 2009

Keywords

  • Respiratory syncytial virus
  • Viral-rna synthesis
  • Nonstructural c protein
  • Induced antiviral state
  • Cysteine-rich domain
  • Double-stranded-rna
  • Measles-virus
  • V-Protein
  • Sendai-virus
  • RIG-I

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