The problem with problems: fundamental to applied research using palladium

Allan J. B. Watson

doi:10.1055/s-0039-1690904

The problem with problems: fundamental to applied research using palladium

Research output: Contribution to journal › Article › peer-review

Abstract

This Account describes the development of our cross-coupling and medicinal chemistry research from its origins at the outset of my independent career through to the present day. Throughout, the decisions and motivations as well as the mistakes and pitfalls are discussed.

Original language	English
Journal	Synlett
Volume	31
Early online date	5 May 2020
DOIs	https://doi.org/10.1055/s-0039-1690904
Publication status	E-pub ahead of print - 5 May 2020

Keywords

Boron
Cross-coupling
Medicinal chemistry
Palladium
Speciation

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10.1055/s-0039-1690904Licence: CC BY

Watson_2020_Synlett_Problems_CC
Copyright © 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution and reproduction, so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Final published version, 935 KBLicence: CC BY

Chemoselective cross-coupling: Chemoselective cross-coupling via control of anion metathesis at Pd(II)
Watson, A. J. B. (PI)
EPSRC
1/07/18 → 31/08/22
Project: Standard
Amine Catalysis: Can amine catalysis generate synthetically useful carbenes
Watson, A. J. B. (PI)
The Leverhulme Trust
1/01/18 → 30/04/18
Project: Standard

Cite this

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title = "The problem with problems: fundamental to applied research using palladium",

abstract = "This Account describes the development of our cross-coupling and medicinal chemistry research from its origins at the outset of my independent career through to the present day. Throughout, the decisions and motivations as well as the mistakes and pitfalls are discussed.",

keywords = "Boron, Cross-coupling, Medicinal chemistry, Palladium, Speciation",

author = "Watson, {Allan J. B.}",

note = "The studies are very grateful for the support we have received from the following sources for the chemistry described in this Account: EPSRC (EP/R025754/1), The Leverhulme Trust (RPG-2015-308), and GlaxoSmithKline and AstraZeneca for several CASE awards and iCASE studentships.",

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KW - Boron

KW - Cross-coupling

KW - Medicinal chemistry

KW - Palladium

KW - Speciation

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M3 - Article

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The problem with problems: fundamental to applied research using palladium

Abstract

Keywords

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Projects

Chemoselective cross-coupling: Chemoselective cross-coupling via control of anion metathesis at Pd(II)

Amine Catalysis: Can amine catalysis generate synthetically useful carbenes

Cite this