The pattern of attentional deficits in Huntington's disease.

Reiner Heinrich Sprengelmeyer, H Lange, V Hoemberg

Research output: Contribution to journalArticlepeer-review

107 Citations (Scopus)

Abstract

Different aspects of attention, e.g. phasic alertness, vigilance, divided attention, response flexibility response inhibition and intermodal integration, were investigated with a computerized test-battery in a group of 20 patients with Huntington's disease and 27 healthy controls. Huntington's disease patients are not impaired in reacting to task-contingent external stimulation in the phasic alertness task but the self-generated maintenance of attention as measured by the vigilance task, is disturbed. The simultaneous monitoring of different input-channels in the divided attention task and the ability to operate with information given to different modalities in the intermodal integration task are severely affected. The performance of Huntington's disease patients in the response flexibility task in which internal cued shifts are required, is impaired Huntington's disease patients are also impaired in reacting selectively to go/no-go stimuli in the response inhibition task. It is suggested that a number of 'higher' cognitive deficits described in Huntington's disease might, at least partly, be due to basic attentional disturbances.

Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalBrain
Volume118
Publication statusPublished - Feb 1995

Keywords

  • ATTENTION
  • EXECUTIVE FUNCTIONS
  • HUNTINGTONS DISEASE
  • BASAL GANGLIA
  • SYSTEM
  • PET

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